I 49 Business; MO 171 $south, I 49 $north; US 71 $north
39.7 mi42 mins
| Head south on South Main Street (MO 43) | 300 feet | |
| Turn left onto East 7th Street (I 44 Business) | 2.0 mi | |
| Turn left onto South Range Line Road (I 49 Business) | 2.7 mi | |
| Continue onto South Madison Street (I 49 Business) | 1.2 mi | |
| Turn right onto West MacArthur Drive (I 49 Business) | 0.9 mi | |
| Enter the roundabout and take the 2nd exit onto I 49 Business | 200 feet | |
| Exit the roundabout onto I 49 Business | 6.5 mi | |
| Merge right onto I 49 Business | 1.3 mi | |
| Continue towards MO 96 East: Carthage | 500 feet | |
| Turn left towards I 49 North: Kansas City | 0.2 mi | |
| Merge left onto I 49 N | 23.1 mi | |
| Take the ramp | 800 feet | |
| Keep right at the fork | 200 feet | |
| Make a slight right onto US 160 | 1.3 mi | |
| Turn right | 0 feet | |
| You have arrived at your destination |
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Joplin, Missouri - Lamar, Missouri