How to get from Key Largo, Florida to St. Petersburg, Florida

Discover, print or download the driving directions for the best route to go from Key Largo, Florida to St. Petersburg, Florida.

Enlarge the route map Key Largo, Florida - St. Petersburg, Florida

Driving directions from Key Largo, Florida to St. Petersburg, Florida

I 75 $north, Alligator Alley

305.5 mi4 hours 40 mins

Head southwest on Overseas Highway (US 1) 500 feet
Make a U-turn and continue on Overseas Highway (US 1) 2.5 mi
Continue onto Dixie Highway (US 1) 19.4 mi
Keep right onto Homestead Extension of Florida's Turnpike 17.3 mi
Keep left onto Homestead Extension of Florida's Turnpike 21.5 mi
Take the ramp towards I 75 North: Naples 1.1 mi
Merge left onto I 75 N 11.2 mi
Keep left towards Alligator Alley 211.0 mi
Take the ramp towards I 275 North: Saint Petersburg 1.2 mi
Continue onto I 275 N 18.1 mi
Take the ramp towards 26th Avenue South 800 feet
Keep left at the fork 200 feet
Turn left onto 26th Avenue South 900 feet
Turn right onto 34th Street South (US 19) 1.8 mi
You have arrived at your destination, on the right

Print directions
Key Largo, Florida - St. Petersburg, Florida

At How to get from we offer the best route to any destination. We use the most advanced technologies of maps representation, route calculation, traffic information updated in real time and distance calculator to give you a detailed itinerary to get to your destination.