Pennsylvania Turnpike, Pennsylvania Turnpike
343.8 mi5 hours 37 mins
| Head north on South Lime Street (US 222) | 1.0 mi | |
| Turn left onto East Liberty Street (US 222) | 600 feet | |
| Turn right onto North Duke Street (US 222) | 500 feet | |
| Continue onto Lititz Pike (US 222) | 0.5 mi | |
| Keep left onto Lititz Pike (US 222) | 0.6 mi | |
| Turn left onto York Road | 600 feet | |
| Take the ramp on the left towards US 30 West: York | 0.2 mi | |
| Merge left onto US 30 | 0.2 mi | |
| Keep left towards PA 283 West: Harrisburg | 28.8 mi | |
| Take the ramp towards I 76 | 0.2 mi | |
| Merge left onto I 283 S | 0.3 mi | |
| Keep right towards I 76 West: Pittsburgh | 0.5 mi | |
| Merge left onto Pennsylvania Turnpike (I 76 W) | 191.1 mi | |
| Take exit 57 towards I 376: Pittsburgh | 0.6 mi | |
| Keep left at the fork | 900 feet | |
| Keep right towards I 376 West: Pittsburgh | 400 feet | |
| Merge right onto Penn-Lincoln Parkway East (I 376 W) | 24.3 mi | |
| Take exit 60A towards US 22 West: Weirton | 26.3 mi | |
| Keep left onto US 22 W | 16.2 mi | |
| Continue onto Cadiz-Steubenville Road (US 22) | 8.4 mi | |
| Take the ramp onto US 250 | 900 feet | |
| Turn right onto Cadiz-Dennison Road (US 250) | 21.2 mi | |
| Take the ramp on the right onto US 250 W | 1.1 mi | |
| Take the ramp towards US 250 West: Uhrichsville | 0.3 mi | |
| Turn right onto Water Street (US 250) | 0.3 mi | |
| Continue onto US 250 W | 11.5 mi | |
| Take exit 83 towards SR 39: Dover | 0.2 mi | |
| Turn left onto State Route 39 (SR 39) | 6.7 mi | |
| Continue onto Dover Road Northeast (SR 39) | 2.4 mi | |
| Continue onto West Main Street (SR 39) | 800 feet | |
| Turn left onto Fair Drive | 0 feet | |
| You have arrived at your destination |
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Lancaster, Pennsylvania - Sugarcreek, Ohio