US 59, US 281 $south
121.3 mi2 hours 3 mins
| Head east on Lafayette Street (US 59 Business) | 600 feet | |
| Continue onto West Saunders Street (US 59 Business) | 64.7 mi | |
| Continue onto TX 44 | 28.8 mi | |
| Turn right onto US Highway 281 Frontage Road | 600 feet | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto US 281 S | 27.2 mi | |
| You have arrived at your destination |
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Laredo, Texas - Premont, Texas