I 59 $north, I 81 $north
769.5 mi11 hours 36 mins
| Head south | 0 feet | |
| Turn left onto West 7th Street | 0.3 mi | |
| Turn right onto North 4th Avenue | 300 feet | |
| Turn left onto Short 6th Street | 800 feet | |
| Continue onto Teresa Street | 900 feet | |
| Continue straight to stay on Teresa Street (US 11) | 200 feet | |
| Continue onto Cross Street (US 11) | 0.2 mi | |
| Turn right onto Chantilly Street | 0.3 mi | |
| Take the ramp on the right | 800 feet | |
| Merge left onto Lance Corporal Roy M Wheat Memorial Highway (I 59 N) | 50.9 mi | |
| Keep right towards I 59 North: Meridian | 129.7 mi | |
| Take the ramp towards I 459 North: Gadsden | 0.5 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 8.7 mi | |
| Continue onto John M Harbert III Freeway (I 459 N) | 2.0 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 22.0 mi | |
| Keep right towards 59: Gadsden | 0.3 mi | |
| Continue towards I-59 North: Gadsden | 900 feet | |
| Merge left onto I 59 N | 123.0 mi | |
| Keep right towards I 24 East: Chattanooga | 0.7 mi | |
| Merge left onto I 24 E | 16.6 mi | |
| Keep left towards Knoxville | 0.6 mi | |
| Merge right onto I 75 N | 72.4 mi | |
| Keep right onto I 75 N | 63.8 mi | |
| Keep left towards I 81 North: Bristol | 148.6 mi | |
| Take the ramp towards I 77 North: Bluefield | 0.7 mi | |
| Continue onto I 77 N | 126.0 mi | |
| Take the ramp towards Leon Sullivan Way | 0.4 mi | |
| Keep left towards Leon Sullivan Way | 800 feet | |
| Continue onto Leon Sullivan Way | 0.4 mi | |
| Turn right onto Kanawha Boulevard East | 0.4 mi | |
| You have arrived at your destination |
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Laurel, Mississippi - Charleston, West Virginia