I 80, William Penn Highway
207.7 mi4 hours 15 mins
| Head south on South Avenue (US 219) | 1.0 mi | |
| Continue onto Buffalo-Pittsburgh Hwy (US 219) | 4.7 mi | |
| Continue onto Buffalo-Pittsburgh Highway (US 219) | 14.1 mi | |
| Continue onto Burning Well Road (US 219) | 3.3 mi | |
| Continue onto Wilcox Road (US 219) | 0.8 mi | |
| Turn left onto Wilcox Road (US 219) | 4.2 mi | |
| Continue onto Market Street (US 219) | 1.2 mi | |
| Continue onto Johnsonburg Bypass (US 219) | 1.2 mi | |
| Continue onto East Center Street (US 219) | 0.3 mi | |
| Continue onto Ridgway-Johnsonburg Road (US 219) | 5.5 mi | |
| Continue onto North Broad Street (US 219) | 0.6 mi | |
| Make a slight right onto N Broad St (US 219) | 1.1 mi | |
| Turn left onto Main Street (US 219) | 0.5 mi | |
| Continue onto Boot Jack Road (US 219) | 16.9 mi | |
| Turn left onto Clark Street (US 219) | 700 feet | |
| Continue onto Cherry Street (US 219) | 7.5 mi | |
| Turn left | 0.3 mi | |
| Merge left onto I 80 | 25.6 mi | |
| Take the ramp towards PA 970 to US 322: Woodland | 0.3 mi | |
| Go straight onto Shawville Highway (PA 970) | 1.4 mi | |
| Turn left onto Woodland Bigler Highway (US 322) | 2.8 mi | |
| Continue onto Philipsburg Bigler Highway (US 322) | 7.1 mi | |
| Continue onto North Front Street (US 322) | 0.3 mi | |
| Continue onto North Centre Street (US 322) | 800 feet | |
| Turn left onto Railroad Street (US 322) | 1.0 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.5 mi | |
| Continue onto Upper Flat Rock Road (US 322) | 1.6 mi | |
| Continue onto Flat Rock Road (US 322) | 1.5 mi | |
| Continue onto 28th Division Highway (US 322 E) | 0.3 mi | |
| Take the ramp towards US 220 Alternate: Port Matilda | 0.2 mi | |
| Continue onto North High Street | 0.6 mi | |
| Take the ramp on the right towards I 99 South: Altoona | 0.4 mi | |
| Merge left onto I 99 S | 12.9 mi | |
| Take the ramp towards PA 453: Tyrone | 0.4 mi | |
| Turn left onto Birmingham Pike (PA 453) | 9.0 mi | |
| Turn left onto William Penn Highway (US 22 E) | 21.4 mi | |
| Turn right onto Croghan Pike (US 522) | 10.8 mi | |
| Continue onto South Ridgley Street (US 522) | 0.5 mi | |
| Continue onto Ridgely Street (US 522) | 900 feet | |
| Continue onto Croghan Pike (US 522) | 4.9 mi | |
| Continue onto Main Street (US 522) | 0.2 mi | |
| Turn left onto Neelyton Road (PA 641) | 0.4 mi | |
| Continue onto Neelyton Rd (PA 641) | 9.8 mi | |
| Turn right onto Timmons Road (PA 641) | 4.0 mi | |
| Continue onto Forge Hill Road (PA 641) | 3.0 mi | |
| Turn right onto Cumberland Highway (PA 997) | 8.7 mi | |
| Make a slight left to stay on Cumberland Highway (PA 997) | 2.3 mi | |
| Keep left onto Black Gap Road (PA 997) | 3.2 mi | |
| Turn right onto Mount Pleasant Road | 2.6 mi | |
| Turn left onto West Main Street | 0.2 mi | |
| You have arrived at your destination, on the left |
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Lewis Run, Pennsylvania - Fayetteville, Pennsylvania