I 65 $south, I 20; I 59 $south
699.1 mi10 hours 56 mins
| Head southwest on South Broadway (US 27) | 500 feet | |
| Turn right onto West High Street (US 60) | 0.9 mi | |
| Continue onto Versailles Road (US 60) | 7.3 mi | |
| Continue onto Lexington Road (US 60) | 1.3 mi | |
| Keep right towards Elizabethtown | 72.0 mi | |
| Merge left onto I 65 S | 125.8 mi | |
| Keep left towards I 24 East: Nashville | 2.4 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep right towards I 40 West: Memphis | 0.4 mi | |
| Merge left onto I 40 | 0.6 mi | |
| Keep left towards I 65 South: Huntsville | 0.4 mi | |
| Merge right onto I 65 S | 28.8 mi | |
| Keep left onto I-65 (I 65 S) | 66.1 mi | |
| Continue onto I 65 (I 65 S) | 0.2 mi | |
| Continue onto I-65 (I 65 S) | 93.0 mi | |
| Take the ramp towards I 20 West: Tuscaloosa | 0.4 mi | |
| Merge left onto I 20 | 146.0 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep left towards I 59 South: Laurel | 53.3 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 S) | 94.3 mi | |
| Take the ramp towards US 11: NASA John C. Stennis Space Center | 0.2 mi | |
| Turn right onto US 11 | 0.5 mi | |
| Turn left onto Jackson Landing Road | 0.3 mi | |
| You have arrived at your destination, on the left |
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Lexington, Kentucky - Nicholson, Mississippi