US 378, I 95 $south
376.6 mi6 hours 7 mins
| Head northeast on US 17 | 100 feet | |
| Make a U-turn and continue on US 17 | 2.5 mi | |
| Take the ramp towards SC 31 | 0.3 mi | |
| Merge left onto SC 9 | 1.8 mi | |
| Make a U-turn and continue on SC 9 | 700 feet | |
| Take the ramp towards SC 31 South: Myrtle Beach | 0.4 mi | |
| Continue onto Carolina Bays Parkway (SC 31 S) | 19.2 mi | |
| Take the ramp towards US 501 North: Carolina Forest | 0.8 mi | |
| Continue onto US 501 | 4.9 mi | |
| Go straight onto US 501 | 3.5 mi | |
| Turn left onto Wright Boulevard (US 378) | 21.9 mi | |
| Keep left onto US 378 | 43.2 mi | |
| Take the ramp on the left towards I 95 South: Savannah | 0.3 mi | |
| Merge left onto I 95 S | 276.6 mi | |
| Take the ramp on the left towards Downtown | 900 feet | |
| Turn left onto Union Street (US 23) | 0.9 mi | |
| Turn right onto Main Street (US 1) | 300 feet | |
| Turn left onto Beaver Street (US 90) | 100 feet | |
| You have arrived at your destination |
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Little River, South Carolina - Jacksonville, Florida