How to get from Louisville, Tennessee to Sanford, North Carolina

Discover, print or download the driving directions for the best route to go from Louisville, Tennessee to Sanford, North Carolina.

Enlarge the route map Louisville, Tennessee - Sanford, North Carolina

Driving directions from Louisville, Tennessee to Sanford, North Carolina

I 40, I 40; US 74 $east; US 64 Truck $east

354.1 mi5 hours 52 mins

Head east on Louisville Road (SR 333) 0.7 mi
Turn left onto Topside Road (SR 333) 5.5 mi
Turn left onto Alcoa Highway (US 129) 7.0 mi
Keep right towards I 40 East: Asheville 500 feet
Keep left towards I 40 East: Asheville 0.4 mi
Merge left onto I 40 34.1 mi
Keep right towards I 40 East: Asheville 217.8 mi
Keep right onto I 40 24.0 mi
Keep left towards I 73 South: Asheboro 12.2 mi
Take the ramp towards US 421: Greensboro 0.2 mi
Keep right towards US 421 South 44.7 mi
Take the ramp onto US 421 Business 0.3 mi
Keep left onto US 421 Business 500 feet
Turn right onto Boone Trail Road (US 421 Business) 3.1 mi
Continue onto North Horner Boulevard (US 421 Business) 3.9 mi
You have arrived at your destination

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Louisville, Tennessee - Sanford, North Carolina

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