US 2, US 20 $west
622.9 mi11 hours 12 mins
| Head southeast on Coal Dock | 300 feet | |
| Take the ferry | 7.5 mi | |
| Turn left | 0.3 mi | |
| Turn right onto South Huron Avenue | 0.3 mi | |
| Turn left onto East Central Avenue | 0.3 mi | |
| Turn right onto North Nicolet Street | 800 feet | |
| Take the ramp on the left towards I 75 North | 200 feet | |
| Merge left onto I 75 N | 5.1 mi | |
| Take exit 344B towards US 2: Manistique | 0.3 mi | |
| Go straight onto I 75 Business | 7.1 mi | |
| Continue onto US 2 | 149.9 mi | |
| Continue onto M 35 | 35.4 mi | |
| Turn left onto 10th Street (US 41) | 1.8 mi | |
| Turn right onto 10th Avenue (US 41) | 0.3 mi | |
| Continue onto Bridge Street (US 41) | 0.4 mi | |
| Continue onto Interstate Bridge (US 41) | 900 feet | |
| Continue onto Hall Avenue (US 41) | 0.5 mi | |
| Continue onto Marinette Avenue (US 41) | 107.4 mi | |
| Take exit 113 towards WI 26: Rosendale | 0.4 mi | |
| Turn right onto State Highway 26 (WI 26 S) | 2.0 mi | |
| Continue onto Waupun Road (WI 26) | 2.6 mi | |
| Continue onto State Highway 26 (WI 26) | 6.2 mi | |
| Continue onto North Main Street (WI 26) | 1.0 mi | |
| Continue onto State Highway 26 (WI 26) | 9.8 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto US 151 | 50.6 mi | |
| Take exit 97A towards I 39 South: Chicago | 0.4 mi | |
| Keep left at the fork | 0.4 mi | |
| Merge left onto I 39 S | 5.6 mi | |
| Take exit 142A towards US 12 West: Madison | 0.6 mi | |
| Merge left onto South Beltline Highway (US 12) | 7.8 mi | |
| Take exit 258A towards Seminole Highway | 0.2 mi | |
| Keep left at the fork | 200 feet | |
| Turn left onto Seminole Highway | 1.6 mi | |
| Turn right onto McKee Road (CTH PD) | 1.0 mi | |
| Make a U-turn and continue on McKee Road (CTH PD) | 500 feet | |
| Turn right onto Verona Road (US 18) | 35.8 mi | |
| Continue towards US 151 South: Platteville | 39.3 mi | |
| Continue onto Great River Road (US 61) | 7.7 mi | |
| Continue onto Dubuque-Wisconsin Bridge (US 61 S) | 2.7 mi | |
| Turn right | 700 feet | |
| Merge right onto South Locust Street | 500 feet | |
| Turn right onto Dodge Street (US 20 W) | 86.9 mi | |
| Take the ramp towards I-380 north: Waterloo | 2.9 mi | |
| Keep left onto US 218 N | 6.3 mi | |
| Take the ramp towards US 218 north: Waverly | 0.2 mi | |
| Keep right onto US 218 N | 0.5 mi | |
| Merge left onto Avenue of the Saints (US 218 N) | 31.6 mi | |
| Take the ramp | 0.4 mi | |
| Turn right onto Sample Street (IA 346) | 0.6 mi | |
| You have arrived at your destination |
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Mackinac Island, Michigan - Nashua, Iowa