I 95 $south, I 81 $south
648.7 mi10 hours 20 mins
| Head west on Boston Post Road (US 1) | 900 feet | |
| Turn right onto Durham Road (CT 79) | 0.7 mi | |
| Take the ramp on the right towards I 95 South | 0.4 mi | |
| Merge left onto I 95 S | 80.7 mi | |
| Keep right towards I-95 north: New England | 0.6 mi | |
| Keep right onto I 95 S | 0.7 mi | |
| Continue onto Cross Bronx Expressway Westbound (I-95 Southbound S) | 0.8 mi | |
| Continue onto Cross Bronx Expressway (I 95 S) | 3.8 mi | |
| Continue onto Trans-Manhattan Expressway (I 95 S) | 500 feet | |
| Keep right onto Trans-Manhattan Expressway (I 95 S) | 0.6 mi | |
| Continue onto George Washington Bridge (lower level) (I 95 S) | 1.7 mi | |
| Continue onto New Jersey Turnpike (I 95) | 5.0 mi | |
| Keep left onto New Jersey Turnpike Western Spur ramp (I 95 S) | 10.3 mi | |
| Take the ramp towards I 78: Newark Airport | 1.4 mi | |
| Keep right at the fork | 700 feet | |
| Make a slight right | 700 feet | |
| Merge left onto Interstate 78 Local (I 78 W) | 400 feet | |
| Take the ramp on the left onto I 78 | 200 feet | |
| Merge left onto Interstate 78 Express (I 78 W) | 59.6 mi | |
| Keep left towards Express E-ZPass Only | 0.3 mi | |
| Merge right onto I 78 W | 21.8 mi | |
| Keep left towards I 78 West: Harrisburg | 53.2 mi | |
| Continue towards I 81 South: Harrisburg | 0.7 mi | |
| Merge left onto I 81 S | 404.5 mi | |
| Take the ramp towards VA 16: Marion | 0.2 mi | |
| Keep right at the fork | 300 feet | |
| Go straight onto South Commerce Street (SR 16) | 0.7 mi | |
| Turn left onto East Main Street (US 11) | 100 feet | |
| You have arrived at your destination |
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Madison, Connecticut - Marion, Virginia