Carretera Interamericana Norte, Autopista José María Castro Madriz
261.9 mi5 hours 46 mins
| Head northwest on 37a Avenida S.E. | 0.2 mi | |
| Turn left to stay on 37a Avenida S.E. | 300 feet | |
| Turn right onto 33a Avenida S.E. | 0.2 mi | |
| Turn left onto Pista de la Solidaridad | 0.9 mi | |
| Enter the roundabout and take the 3rd exit | 500 feet | |
| Exit the roundabout | 0.2 mi | |
| Continue onto Carretera Managua - Masaya (NIC-4) | 0.4 mi | |
| Enter Rotonda Jean-Paul Genie and take the 2nd exit onto Carretera Managua - Masaya (NIC-4) | 200 feet | |
| Exit the roundabout onto Carretera Managua - Masaya (NIC-4) | 4.7 mi | |
| Enter NIC-4 and take the 2nd exit onto Carretera Managua - Masaya (NIC-4) | 100 feet | |
| Exit the roundabout onto Carretera Managua - Masaya (NIC-4) | 8.0 mi | |
| Enter the roundabout and take the 1st exit onto Avenida Bolívar | 200 feet | |
| Exit the roundabout onto Avenida Bolívar | 0.2 mi | |
| Turn right onto Avenida de las Diligencias | 1.7 mi | |
| Turn left onto Calle San Miguel | 300 feet | |
| Turn right onto Avenida Real de Monimbó | 1.2 mi | |
| Turn right onto NIC-11B | 3.5 mi | |
| Enter the roundabout and take the 2nd exit onto NIC-18 | 300 feet | |
| Exit the roundabout onto NIC-18 | 3.6 mi | |
| Continue straight to stay on NIC-18 | 2.1 mi | |
| Keep right at the fork | 800 feet | |
| Continue slightly right onto NIC-18 | 5.7 mi | |
| Merge right onto Pan American Highway (NIC-2) | 29.0 mi | |
| Enter the roundabout and take the 2nd exit onto NIC-2 | 100 feet | |
| Exit the roundabout onto NIC-2 | 22.0 mi | |
| Continue straight to stay on Carretera Panamericana (NIC-2) | 0.3 mi | |
| Continue onto Carretera Interamericana Norte (1) | 47.2 mi | |
| Enter Carretera Interamericana Norte and take the 3rd exit onto Carretera Interamericana Norte (1) | 200 feet | |
| Exit the roundabout onto Carretera Interamericana Norte (1) | 29.5 mi | |
| Continue straight to stay on Carretera Interamericana Norte (1) | 45.1 mi | |
| Take the ramp onto 23 | 600 feet | |
| Merge left onto Ruta Nacional 23 (23) | 7.2 mi | |
| Continue onto Autopista José María Castro Madriz (27) | 38.8 mi | |
| Continue onto Autopista Próspero Fernández (27) | 6.1 mi | |
| Keep right onto Autopista Próspero Fernández (27) | 2.6 mi | |
| Turn left onto Avenida San Martín | 0.9 mi | |
| You have arrived at your destination |
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Managua - San José, San José