I 59 $north, I 81 $north
1,463.4 mi22 hours 56 mins
| Head west on J M Tatum Industrial Drive | 0.7 mi | |
| Turn right onto US 49 | 7.3 mi | |
| Take the ramp on the right towards North I 59: Laurel | 0.3 mi | |
| Merge left towards Laurel | 27.4 mi | |
| Continue towards North I 59: Meridian | 0.5 mi | |
| Continue onto Lance Corporal Roy M Wheat Memorial Highway (I 59 N) | 52.2 mi | |
| Keep right towards I 59 North: Meridian | 129.7 mi | |
| Take the ramp towards I 459 North: Gadsden | 0.5 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 8.7 mi | |
| Continue onto John M Harbert III Freeway (I 459 N) | 2.0 mi | |
| Continue onto John M. Harbert III Freeway (I 459 N) | 22.0 mi | |
| Keep right towards 59: Gadsden | 0.3 mi | |
| Continue towards I-59 North: Gadsden | 900 feet | |
| Merge left onto I 59 N | 123.0 mi | |
| Keep right towards I 24 East: Chattanooga | 0.7 mi | |
| Merge left onto I 24 E | 16.6 mi | |
| Keep left towards Knoxville | 0.6 mi | |
| Merge right onto I 75 N | 72.4 mi | |
| Keep right onto I 75 N | 63.8 mi | |
| Keep left towards I 81 North: Bristol | 526.2 mi | |
| Keep right towards I 78 East: Allentown | 50.9 mi | |
| Keep left towards I 78 East: New Jersey | 74.5 mi | |
| Keep left onto Interstate 78 Express (I 78 E) | 10.2 mi | |
| Take the ramp | 300 feet | |
| Keep left at the fork | 1.4 mi | |
| Keep right at the fork | 0.9 mi | |
| Merge left onto New Jersey Turnpike (I 95 N) | 10.3 mi | |
| Take the ramp towards US 46: The Ridgefields | 800 feet | |
| Keep right towards US 46 East: Ridgefield | 0.3 mi | |
| Merge right onto US 46 | 2.7 mi | |
| Take the ramp on the left | 600 feet | |
| Merge left onto I 95 | 1.7 mi | |
| Continue onto Trans-Manhattan Expressway (I 95 N) | 0.7 mi | |
| Continue onto Cross Bronx Expressway (I 95 N) | 4.7 mi | |
| Keep left onto I 95 N | 2.9 mi | |
| Take exit 9 towards Hutchinson Parkway North | 400 feet | |
| Keep left towards Hutchinson River Parkway North | 0.2 mi | |
| Merge left onto Hutchinson River Parkway (HRP N) | 1.5 mi | |
| Take exit 6 towards I 95 North: New Haven | 0.3 mi | |
| Merge left onto New England Thruway (I 95 N) | 3.7 mi | |
| Keep right onto New England Thruway (I 95 N) | 100 feet | |
| Merge right onto New England Thruway (I 95 N) | 55.5 mi | |
| Take the ramp towards I 91 North: Hartford | 0.6 mi | |
| Continue onto I 91 | 36.4 mi | |
| Take the ramp towards US 5 North: East Hartford | 0.4 mi | |
| Merge left onto Charter Oak Bridge (US 5) | 0.4 mi | |
| Continue onto Wilbur Cross Highway (CT 15 N) | 42.1 mi | |
| Keep right towards I 90 East: New Hampshire | 0.4 mi | |
| Merge left onto Massachusetts Turnpike (I 90 E) | 11.2 mi | |
| Take exit 10 towards I 395: Auburn | 0.3 mi | |
| Keep left at the fork | 0.7 mi | |
| Continue onto I 290 E | 20.1 mi | |
| Keep left towards I 495 North: Lowell | 0.7 mi | |
| Merge left onto I 495 N | 55.6 mi | |
| Merge left onto I 95 N | 13.6 mi | |
| Take exit 3 towards NH 33: Greenland | 0.7 mi | |
| Turn right onto Greenland Road (NH 33) | 0.8 mi | |
| Continue onto Middle Road (NH 33) | 0.8 mi | |
| Keep right onto South Street (NH 33) | 800 feet | |
| Turn left onto Lafayette Road (US 1) | 0.2 mi | |
| You have arrived at your destination |
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Mars Hill, Hattiesburg, Mississippi - Portsmouth, New Hampshire