I 79 $south, I 64 $west
442.8 mi7 hours 33 mins
| Head northwest on WV 42 | 11.4 mi | |
| Turn left onto WV 93 | 800 feet | |
| Take the ramp on the left | 900 feet | |
| Turn right onto Corridor H (US 48) | 16.3 mi | |
| Turn right onto WV 32 | 2.2 mi | |
| Turn left onto Seneca Trail (US 219) | 13.3 mi | |
| Make a slight left onto Magnolia Street (US 219) | 200 feet | |
| Continue onto 1st Street (US 219) | 0.4 mi | |
| Turn left onto Main Street (US 219) | 2.6 mi | |
| Turn left onto County Route 39 | 2.7 mi | |
| Go straight onto Pleasant Run Road (County Route 47) | 3.7 mi | |
| Continue slightly right onto Wilmoth Road (County Route 3) | 1.9 mi | |
| Turn left onto US 219 | 1.3 mi | |
| Take the ramp onto US 219 | 40.5 mi | |
| Take the ramp towards US 33: Weston | 0.2 mi | |
| Merge left onto I 79 S | 98.2 mi | |
| Merge right onto I 77 S | 1.4 mi | |
| Take the ramp towards I 64 West: Huntington | 900 feet | |
| Keep left at the fork | 0.5 mi | |
| Merge right onto I 64 W | 167.7 mi | |
| Keep right towards I 64 West: Louisville | 6.9 mi | |
| Keep left towards I 64 West: Frankfort | 70.6 mi | |
| Take the ramp towards 9th Street | 0.5 mi | |
| Keep right at the fork | 300 feet | |
| Go straight onto West Jefferson Street | 300 feet | |
| You have arrived at your destination |
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Maysville, West Virginia - Louisville, Kentucky