New York State Thruway, Highway 401
669.3 mi10 hours 52 mins
| Head southeast on East Main Street | 0.4 mi | |
| Turn left onto Broad Street (US 5) | 0.6 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto I 691 E | 0.9 mi | |
| Take exit 11 on the left towards I 91 North: Hartford | 0.5 mi | |
| Merge left onto I 91 N | 17.0 mi | |
| Keep right onto I 91 N | 31.8 mi | |
| Take exit 14 towards I 90 Toll: Boston | 0.7 mi | |
| Keep right towards I 90 | 0.2 mi | |
| Keep right towards I 90 West: Albany | 0.4 mi | |
| Merge left onto Massachusetts Turnpike (I 90 W) | 45.3 mi | |
| Continue onto New York State Thruway Berkshire Connector (I 90 W) | 6.4 mi | |
| Merge right onto New York State Thruway Berkshire Connector (I 90 W) | 17.7 mi | |
| Keep right towards I 87 North: Albany | 0.5 mi | |
| Merge left onto New York State Thruway (I 87 N) | 285.4 mi | |
| Take exit 50 towards I 290: Niagara Falls | 0.4 mi | |
| Continue slightly right onto Youngmann Expressway (I 290 W) | 9.5 mi | |
| Keep right towards I 190 North: Niagara Falls | 0.3 mi | |
| Merge left onto Niagara Thruway (I 190 N) | 6.8 mi | |
| Continue onto North Grand Island Bridge (I 190 N) | 0.8 mi | |
| Continue onto Niagara Thruway (I 190 N) | 7.2 mi | |
| Continue onto Queenston–Lewiston Bridge (405) | 800 feet | |
| Continue onto General Brock Parkway (405) | 5.8 mi | |
| Merge left onto Queen Elizabeth Way (QEW N) | 30.8 mi | |
| Take the ramp towards 20 | 0.4 mi | |
| Keep right towards Red Hill Valley Parkway | 0.8 mi | |
| Continue onto Red Hill Valley Parkway | 5.2 mi | |
| Continue onto Lincoln M. Alexander Parkway | 6.3 mi | |
| Keep right towards 403 East: Highway 403 | 500 feet | |
| Keep left towards 403 West: Brantford | 0.7 mi | |
| Merge left onto Alexander Graham Bell Parkway (403 S) | 40.3 mi | |
| Merge left onto Highway 401 (401 W) | 31.0 mi | |
| Keep left onto Highway 401 (401 W) | 105.9 mi | |
| Keep right onto Dougall Parkway | 1.9 mi | |
| Continue onto Dougall Avenue | 2.3 mi | |
| Go straight onto Ouellette Place | 700 feet | |
| Continue onto Ouellette Avenue | 2.3 mi | |
| Turn right onto Wyandotte Street East | 600 feet | |
| Turn left onto Detroit-Windsor Tunnel | 1.4 mi | |
| Continue onto Randolph Street (M 3 N) | 800 feet | |
| Turn left onto Cadillac Square | 800 feet | |
| Turn right onto Woodward Avenue | 100 feet | |
| Turn left to stay on Woodward Avenue | 400 feet | |
| Turn right onto Michigan Avenue | 300 feet | |
| You have arrived at your destination |
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Meriden, Connecticut - Detroit, Michigan