William Penn Highway, American Legion Memorial Highway
65.9 mi1 hour 14 mins
| Head west on Main Street | 2.3 mi | |
| Turn left onto Shartlesville Road | 4.1 mi | |
| Turn right to stay on Shartlesville Road | 1.0 mi | |
| Go straight onto Old Route 22 | 1.1 mi | |
| Turn right onto Mountain Road | 900 feet | |
| Take the ramp on the left towards I 78 West: Harrisburg | 0.2 mi | |
| Merge left onto William Penn Highway (I 78 W) | 14.4 mi | |
| Continue onto 78th Division Highway (I 78 W) | 7.6 mi | |
| Continue towards I 81 South: Harrisburg | 0.7 mi | |
| Merge left onto I 81 S | 18.2 mi | |
| Take the ramp on the left towards South Harrisburg | 0.9 mi | |
| Continue onto Veterans of Foreign Wars of the United States Memorial Highway (I 83 S) | 2.9 mi | |
| Keep left onto Veterans of Foreign Wars of the United States Memorial Highway (I 83 S) | 0.8 mi | |
| Keep right towards I 83 South: Harrisburg | 4.6 mi | |
| Keep left towards PA 581 West: Camp Hill | 3.3 mi | |
| Take the ramp towards PA 641: Mechanicsburg | 700 feet | |
| Keep right towards PA 641 | 300 feet | |
| Go straight onto Central Boulevard | 300 feet | |
| Turn right onto Trindle Road (PA 641 W) | 2.8 mi | |
| Continue onto East Main Street (PA 641) | 0.6 mi | |
| You have arrived at your destination |
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Mohrsville, Pennsylvania - Mechanicsburg, Pennsylvania