I 73 $south; I 74 $east; US 220 $south, US 501
257.9 mi4 hours 44 mins
| Head southeast on South Main Street | 0.6 mi | |
| Turn right onto South Renfro Street (US 52 Business) | 200 feet | |
| Continue onto South Main Street (US 52 Business) | 2.3 mi | |
| Turn left onto South Andy Griffith Parkway (US 52 S) | 1.8 mi | |
| Keep left onto US 52 S | 34.1 mi | |
| Take the ramp towards I 40 East: Greensboro | 2.5 mi | |
| Take the ramp towards US 311 South: High Point | 31.3 mi | |
| Keep right onto I 74 E | 60.3 mi | |
| Continue onto US 220 | 3.2 mi | |
| Continue onto US 1 | 1.2 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto I 74 E | 24.4 mi | |
| Take the ramp towards US 501 South: Rowland | 900 feet | |
| Keep right onto South Caledonia Road (US 501) | 0.5 mi | |
| Continue onto Johns Road (US 501) | 18.4 mi | |
| Turn right onto South Bond Street (US 301) | 16.7 mi | |
| Make a slight left onto US 501 | 3.1 mi | |
| Keep left onto US 501 | 12.7 mi | |
| Keep right at the fork | 0.4 mi | |
| Turn left onto US 501 Business | 43.8 mi | |
| You have arrived at your destination |
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Mt Airy, North Carolina - Myrtle Beach, South Carolina