I 75 $north, I 65 $north
948.8 mi15 hours 21 mins
| Head northwest on 5th Avenue North | 0.2 mi | |
| Turn right onto North Kings Highway (US 17 Business) | 0.3 mi | |
| Turn left onto 8th Avenue North | 200 feet | |
| Continue onto Main Street (US 501) | 10.8 mi | |
| Go straight onto US 501 | 33.2 mi | |
| Go straight onto SC 576 N | 3.2 mi | |
| Continue onto US 76 | 22.5 mi | |
| Turn right onto I 20 Business | 79.0 mi | |
| Take the ramp towards I 26 West: Spartanburg | 0.5 mi | |
| Merge left onto I 26 W | 133.6 mi | |
| Continue onto I 26 W | 12.7 mi | |
| Take the ramp on the left towards I 40 West: Canton | 110.1 mi | |
| Take the ramp towards I 275 North: Lexington | 0.4 mi | |
| Continue onto I 275 N | 3.0 mi | |
| Continue onto I 75 N | 171.1 mi | |
| Keep left towards I 64 West: Frankfort | 68.3 mi | |
| Take the ramp on the left towards I 65: Nashville | 0.8 mi | |
| Keep right towards I 65 North: Indianapolis | 0.3 mi | |
| Merge left onto Abraham Lincoln Bridge (I 65) | 112.4 mi | |
| Keep left onto I 65 N | 147.0 mi | |
| Take the ramp towards US 80 West: Chicago | 1.4 mi | |
| Merge left onto Borman Expressway (I 80) | 10.6 mi | |
| Continue onto Kingery Expressway (I 80) | 1.4 mi | |
| Continue onto Tri-State Tollway (I 80) | 6.1 mi | |
| Keep left onto Tri-State Tollway (I 294 N) | 0.8 mi | |
| Keep right onto Tri-State Tollway (I 294 N) | 13.9 mi | |
| Keep left onto Tri-State Tollway (I 294 N) | 1.9 mi | |
| Continue onto Mile-Long Bridge (I 294 N) | 0.8 mi | |
| Take the ramp towards 75th Street | 0.5 mi | |
| Turn left onto 75th Street | 0.2 mi | |
| Continue left onto Santa Fe Drive | 1.4 mi | |
| Continue onto East Avenue | 0.2 mi | |
| Turn right onto Lyons Street | 300 feet | |
| You have arrived at your destination |
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Myrtle Beach, South Carolina - Hodgkins, Illinois