How to get from Naples, FL to Key West, FL

Discover, print or download the driving directions for the best route to go from Naples, FL to Key West, FL.

Enlarge the route map Naples, FL - Key West, FL

Driving directions from Naples, FL to Key West, FL

Tamiami Trail, Overseas Highway

239.3 mi4 hours 49 mins

Head north on 8th Street South 900 feet
Turn right onto 5th Avenue South 0.9 mi
Continue onto Tamiami Trail (US 41) 88.2 mi
Continue onto Southwest 8th Street (US 41) 1.0 mi
Turn right onto Southwest 177th Avenue (FL 997) 20.2 mi
Turn left onto East Mowry Drive 0.3 mi
Turn right onto North Homestead Boulevard (US 1) 0.4 mi
Continue onto South Dixie Highway (US 1) 20.2 mi
Continue onto Overseas Highway (US 1) 104.0 mi
Keep right onto US 1 2.9 mi
Turn right onto White Street 0.3 mi
Turn left onto Southard Street 0.5 mi
Turn left onto Simonton Street 400 feet
Turn right onto Angela Street 100 feet
You have arrived at your destination

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Naples, FL - Key West, FL

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