I 77 $south, West Virginia Turnpike
323.6 mi5 hours 9 mins
| Head southeast on Canal Street (Business US 33) | 1.7 mi | |
| Turn left onto Happy Hollow Road (SR 691) | 0.2 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto Nelsonville Bypass (US 33 E) | 10.5 mi | |
| Keep right towards US 33 East: Pomeroy | 0.2 mi | |
| Merge left onto James A. Rhodes Appalachian Highway (US 33 E) | 1.9 mi | |
| Keep right onto US 33 E | 19.0 mi | |
| Continue onto SR 833 | 1,000 feet | |
| Make a U-turn and continue on SR 124 | 1,000 feet | |
| Take the ramp onto SR 124 | 0.2 mi | |
| Turn right onto US 33 E | 18.6 mi | |
| Turn left onto US 33 | 2.7 mi | |
| Take the ramp onto US 33 E | 800 feet | |
| Merge left onto I 77 S | 145.2 mi | |
| Continue onto I 77 S | 26.5 mi | |
| Keep right towards I 81 South: Bristol | 0.4 mi | |
| Merge left onto I 81 S | 56.1 mi | |
| Continue onto I 81 S | 12.0 mi | |
| Take the ramp towards I 381: Bristol | 0.8 mi | |
| Continue onto I 381 S | 1.0 mi | |
| Continue onto Commonwealth Avenue | 1.2 mi | |
| Continue onto Volunteer Parkway (US 11E) | 6.8 mi | |
| Continue onto Bristol Highway (US 11E) | 13.9 mi | |
| Turn left onto North Roan Street (US 11E) | 0.8 mi | |
| Take the ramp onto US 19W S | 2.8 mi | |
| Take the ramp towards TN 91 | 1,000 feet | |
| Make a slight left onto East Main Street (SR 91) | 900 feet | |
| Make a sharp left onto Legion Street (SR 91) | 200 feet | |
| You have arrived at your destination |
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Nelsonville, Ohio - Johnson City, Tennessee