I 280 $west, Grand Army of the Republic Highway
105.7 mi2 hours 13 mins
| Head northwest on Chambers Street | 300 feet | |
| Turn right onto Church Street | 0.2 mi | |
| Keep left onto 6th Avenue | 0.3 mi | |
| Make a slight left onto Canal Street | 800 feet | |
| Take the ramp on the right towards I 78: Holland Tunnel | 400 feet | |
| Continue slightly left onto Holland Tunnel access | 1.7 mi | |
| Continue onto 14th Street | 0.5 mi | |
| Keep left onto 14th Street Viaduct (NJ 139) | 0.4 mi | |
| Continue onto Route 139 (Lower Level) Westbound (NJ 139) | 0.7 mi | |
| Continue onto Pulaski Skyway (NJ 139) | 600 feet | |
| Take the ramp towards US 1-9: Newark | 0.5 mi | |
| Continue onto US 1-9 Truck (US 1 Truck) | 0.7 mi | |
| Keep right onto NJ 7 | 1.3 mi | |
| Keep left onto Newark Turnpike (CR 508) | 2.7 mi | |
| Continue onto Harrison Avenue (CR 508) | 0.8 mi | |
| Turn right onto North 2nd Street | 100 feet | |
| Continue straight to stay on North 2nd Street | 100 feet | |
| Take the ramp on the left | 0.2 mi | |
| Merge right onto I 280 W | 14.0 mi | |
| Keep left at the fork | 0.5 mi | |
| Merge right onto I 80 W | 11.4 mi | |
| Take the ramp towards SH 15: Wharton | 0.6 mi | |
| Continue onto NJ 15 North (NJ 15) | 17.2 mi | |
| Continue onto Hampton House Road (US 206) | 15.1 mi | |
| Go straight onto US 206 | 2.2 mi | |
| Continue onto Grand Army of the Republic Highway (US 6 W) | 22.4 mi | |
| Continue onto Lake Wallenpaupack Road (US 6 W) | 1.4 mi | |
| Continue onto Welwood Avenue (US 6 W) | 0.6 mi | |
| Continue onto Bellemonte Avenue (US 6 W) | 0.8 mi | |
| Continue onto Spring Street (US 6 W) | 400 feet | |
| Continue onto Main Avenue (US 6 W) | 0.5 mi | |
| Turn left onto Hudson Street (US 6 W) | 0.2 mi | |
| Continue onto Texas Palmyra Highway (US 6 W) | 6.9 mi | |
| Continue onto Grandview Avenue (US 6 W) | 0.5 mi | |
| Continue onto Willow Avenue (US 6 W) | 0.6 mi | |
| Continue slightly right onto Church Street (US 6 W) | 0.4 mi | |
| Turn left onto 9th Street | 300 feet | |
| Turn left onto Main Street (US 6 E) | 200 feet | |
| You have arrived at your destination |
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New York - Honesdale, Pennsylvania