US 23, US 52
170.8 mi3 hours 3 mins
| Head west on West Locust Street | 400 feet | |
| Turn right onto Mount Vernon Road (SR 13) | 900 feet | |
| Take the ramp on the left towards SR 16 West: Columbus | 0.3 mi | |
| Merge left onto SR 16 W | 400 feet | |
| Take the ramp towards SR 79 South: Heath | 600 feet | |
| Keep left onto SR 79 S | 9.5 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto I 70 | 19.2 mi | |
| Take the ramp towards Cleveland | 0.2 mi | |
| Keep left towards I 270 South: Cincinnati | 0.3 mi | |
| Keep right towards I 270 South: Cincinnati | 0.4 mi | |
| Keep left at the fork | 0.6 mi | |
| Continue onto Jack Nicklaus Freeway (I 270 S) | 9.2 mi | |
| Take the ramp towards US 23 South: Circleville | 0.3 mi | |
| Continue onto South High Street (US 23) | 3.0 mi | |
| Continue onto Portsmouth – Columbus Road (US 23) | 36.6 mi | |
| Keep right onto US 23 | 31.5 mi | |
| Take the ramp towards SR 823 South: Ironton | 0.5 mi | |
| Continue towards SR 823 South: Ironton | 16.6 mi | |
| Merge left onto US 52 E | 34.7 mi | |
| Continue onto Chesapeake Bypass (SR 7) | 2.1 mi | |
| Take the ramp onto SR 7 | 0.6 mi | |
| Turn left onto 3rd Avenue (SR 7) | 700 feet | |
| Continue onto Rockwood Avenue (SR 7) | 4.0 mi | |
| Continue onto State Street (CR 107) | 0.3 mi | |
| You have arrived at your destination |
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Newark, Ohio - Proctorville, Ohio