New York State Thruway, I 81 $south
311.6 mi5 hours 34 mins
| Head west on Goat Island Road | 200 feet | |
| Go straight | 800 feet | |
| Continue slightly left onto Goat Island Road | 900 feet | |
| Turn left to stay on Goat Island Road | 0.4 mi | |
| Continue onto American Rapids Bridge | 800 feet | |
| Continue onto 1st Street | 500 feet | |
| Enter the roundabout and take the 1st exit onto Rainbow Boulevard | 0 feet | |
| Exit the roundabout onto Rainbow Boulevard | 0.5 mi | |
| Turn right onto John B. Daly Boulevard | 0.2 mi | |
| Enter the roundabout and take the 2nd exit onto Niagara Scenic Parkway (NSP S) | 200 feet | |
| Exit the roundabout onto Niagara Scenic Parkway (NSP S) | 2.9 mi | |
| Take the ramp on the left towards I 190: Buffalo | 700 feet | |
| Keep right at the fork | 1,000 feet | |
| Continue onto North Grand Island Bridge (I 190 S) | 0.8 mi | |
| Continue onto Niagara Thruway (I 190 S) | 6.8 mi | |
| Take exit 16 towards I 290 East: Tonawanda | 0.4 mi | |
| Continue onto Youngmann Expressway (I 290 E) | 9.4 mi | |
| Keep left towards I 90 East: Albany | 0.6 mi | |
| Merge left onto New York State Thruway (I 90 E) | 130.2 mi | |
| Take exit 39 towards I 690: Syracuse | 0.7 mi | |
| Keep right towards I 690 East: Fairgrounds | 0.2 mi | |
| Continue onto I 690 E | 8.7 mi | |
| Take the ramp towards I 81 South: Binghamton | 0.2 mi | |
| Merge left onto I 81 S | 71.9 mi | |
| Merge right onto I 81 E | 4.3 mi | |
| Keep left towards New York | 35.9 mi | |
| Take exit 87 towards NY 97: Hancock | 900 feet | |
| Turn left onto West Main Street (NY 97) | 500 feet | |
| Turn right onto West Front Street | 0.8 mi | |
| Turn right onto State Highway 97 (NY 97) | 200 feet | |
| Continue onto Stockport Road (NY 97) | 0.2 mi | |
| Continue onto State Highway 97 (NY 97) | 22.9 mi | |
| Turn left onto Mill Street (NY 17B) | 400 feet | |
| Make a slight left onto State Highway 17B (NY 17B) | 5.1 mi | |
| Turn right to stay on State Highway 17B (NY 17B) | 1.7 mi | |
| Turn left to stay on State Highway 17B (NY 17B) | 5.5 mi | |
| You have arrived at your destination |
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Niagara Falls - Bethel, New York