I 81 $south, I 59 $south
1,116.9 mi17 hours 19 mins
| Head south on Laubach Avenue | 0.5 mi | |
| Turn left onto Main Street | 1.4 mi | |
| Turn left onto 4th Street | 500 feet | |
| Turn right onto Cypress Street | 400 feet | |
| Continue onto Eugene Street | 900 feet | |
| Continue onto Lehigh Street | 1.2 mi | |
| Turn left onto MacArthur Road (PA 145 S) | 2.0 mi | |
| Take the ramp towards US 22 West: Harrisburg | 0.2 mi | |
| Merge left onto Lehigh Valley Thruway (US 22 W) | 6.2 mi | |
| Merge left onto William Penn Highway (I 78 W) | 43.1 mi | |
| Continue onto 78th Division Highway (I 78 W) | 7.6 mi | |
| Continue towards I 81 South: Harrisburg | 0.7 mi | |
| Merge left onto I 81 S | 526.3 mi | |
| Merge left onto I 40 | 52.7 mi | |
| Keep left towards I 75 South: Chattanooga | 10.2 mi | |
| Keep right onto I 75 S | 800 feet | |
| Keep left onto I 75 S | 72.9 mi | |
| Take the ramp towards I 24 West: Chattanooga | 0.6 mi | |
| Continue towards Chattanooga | 16.7 mi | |
| Take exit 167 on the left towards I 59 South: Birmingham | 0.8 mi | |
| Continue onto I 59 S | 123.2 mi | |
| Take exit 137 on the left towards I-459 South: Tuscaloosa | 0.5 mi | |
| Continue onto John M. Harbert III Freeway (I 459 S) | 22.0 mi | |
| Continue onto I-459 S | 2.0 mi | |
| Continue onto John M. Harbert III Freeway (I 459 S) | 8.6 mi | |
| Keep left towards I 20 West: Tuscaloosa | 1.2 mi | |
| Merge left onto I 20 | 126.9 mi | |
| Continue onto I 20 | 1.8 mi | |
| Keep right towards I 20 West: Jackson | 85.1 mi | |
| Merge left onto I 20 | 0.3 mi | |
| Take the ramp towards US 51 North | 0.3 mi | |
| Go straight onto South State Street (US 51 N) | 1.3 mi | |
| You have arrived at your destination |
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Northampton, Pennsylvania - Jackson, Mississippi