I 75 $south, I 75 $south; US 23 $south
260.5 mi4 hours 32 mins
| Head west on West Nagonaba Street (M 201) | 100 feet | |
| Turn left onto South Waukazoo Street (M 201) | 700 feet | |
| Turn right onto Main Street (M 201) | 300 feet | |
| Turn left onto South Shabwasung Street (M 201) | 0.2 mi | |
| Continue onto North West Bay Shore Drive | 11.5 mi | |
| Continue onto Saint Joseph Street (M 22) | 0.5 mi | |
| Continue onto South West-Bay Shore Drive | 0.5 mi | |
| Continue onto South West Bay Shore Drive | 14.3 mi | |
| Continue onto West Grandview Parkway (M 22 N) | 1.8 mi | |
| Continue slightly left onto East Front Street (US 31) | 1.1 mi | |
| Continue onto Munson Avenue (US 31) | 5.7 mi | |
| Turn right onto M-72 (M 72) | 0.8 mi | |
| Enter the roundabout and take the 2nd exit onto M-72 (M 72 E) | 100 feet | |
| Exit the roundabout onto M-72 (M 72 E) | 0.4 mi | |
| Enter the roundabout and take the 2nd exit onto M-72 (M 72 E) | 100 feet | |
| Exit the roundabout onto M-72 (M 72 E) | 13.0 mi | |
| Continue onto West Mile Road (M 72) | 2.8 mi | |
| Turn right onto North Cedar Street (US 131) | 2.0 mi | |
| Turn left onto State Highway 72 (M 72) | 16.9 mi | |
| Continue onto West M-72 | 7.3 mi | |
| Continue onto Lake Street (M 72) | 400 feet | |
| Turn right onto North James Street (I 75 Business) | 1.7 mi | |
| Merge left onto I 75 S | 139.0 mi | |
| Take the ramp towards US 23: Ann Arbor | 600 feet | |
| Continue towards US 23: Ann Arbor | 30.9 mi | |
| Take the ramp on the left towards I 96 East: Detroit | 0.3 mi | |
| Keep left towards I 96 West: Detroit | 0.6 mi | |
| Merge left onto I 96 E | 4.3 mi | |
| Take the ramp towards South Lyon | 0.2 mi | |
| Turn left onto Grand River Avenue | 200 feet | |
| Turn right onto Kent Lake Road | 0.9 mi | |
| Turn left onto Silver Lake Road | 0.2 mi | |
| Turn right onto Pontiac Trail | 2.0 mi | |
| Continue onto North Lafayette Street | 1.0 mi | |
| Turn right onto West Lake Street | 500 feet | |
| You have arrived at your destination |
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Northport, Michigan - South Lyon, Michigan