I 73 $south; I 74 $east; US 220 $south, I 74 $east; US 74 $east
307.3 mi5 hours 17 mins
| Head southeast on North Main Street (US 460 Business) | 0.5 mi | |
| Continue onto Pulaski Giles Turnpike (VA 100) | 11.4 mi | |
| Continue onto Cleburne Boulevard (VA 100) | 9.6 mi | |
| Take the ramp | 0.7 mi | |
| Continue onto I 81 S | 16.4 mi | |
| Take the ramp towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue towards I 77 South: Charlotte NC | 0.4 mi | |
| Continue onto I 77 S | 36.7 mi | |
| Take the ramp on the left towards I 74 East: Mount Airy | 12.7 mi | |
| Continue onto Pilot Mountain Parkway (US 52 S) | 33.1 mi | |
| Take the ramp towards I 40 East: Greensboro | 2.5 mi | |
| Take the ramp towards US 311 South: High Point | 31.3 mi | |
| Keep right onto I 74 E | 60.3 mi | |
| Continue onto US 220 | 3.2 mi | |
| Continue onto US 1 | 1.2 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto I 74 E | 65.4 mi | |
| Continue onto US 74 E | 16.2 mi | |
| Take the ramp | 0.3 mi | |
| Keep right at the fork | 300 feet | |
| Go straight onto US 701 Bypass | 3.2 mi | |
| Turn left onto West Love Mill Road (NC 130) | 0.2 mi | |
| Continue onto Vinson Boulevard (NC 130) | 1.3 mi | |
| You have arrived at your destination |
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Pearisburg, Virginia - Brunswick, North Carolina