I 78 $west, US 222
150.1 mi2 hours 41 mins
| Head west on Lakeside Avenue | 900 feet | |
| Turn left onto Colfax Avenue (CR 686) | 200 feet | |
| Turn left onto Wanaque Avenue (CR 684) | 0.4 mi | |
| Keep right onto Wanaque Avenue (CR 684) | 200 feet | |
| Go straight onto Paterson-Hamburg Turnpike (CR 689) | 1.0 mi | |
| Take the ramp on the left towards NJ 23 South: Riverdale | 0.3 mi | |
| Merge left onto I-287 Southbound (I 287) | 32.1 mi | |
| Take the ramp towards I 78 West: Easton | 0.3 mi | |
| Merge left onto I 78 W | 31.7 mi | |
| Keep left towards Express E-ZPass Only | 0.3 mi | |
| Merge right onto I 78 W | 21.3 mi | |
| Take exit 54A towards US 222 South: Hamilton Boulevard | 0.4 mi | |
| Continue onto Hamilton Blvd Bypass (US 222) | 5.2 mi | |
| Keep right onto Trexlertown Bypass (US 222) | 0.4 mi | |
| Continue onto Hamilton Boulevard (US 222) | 3.1 mi | |
| Continue onto Kutztown Road (US 222) | 9.6 mi | |
| Enter the roundabout and take the 2nd exit onto Allentown Pike (US 222) | 100 feet | |
| Exit the roundabout onto Allentown Pike (US 222) | 4.7 mi | |
| Continue onto Kutztown Road (US 222) | 0.3 mi | |
| Continue onto Allentown Pike (US 222) | 2.4 mi | |
| Continue onto North 5th Street Highway (US 222 Business) | 2.3 mi | |
| Take the ramp on the right towards PA 12 West: Lebanon | 0.3 mi | |
| Merge left onto Warren Street Bypass (PA 12 W) | 30.0 mi | |
| Keep left towards US 30 East: Philadelphia | 0.7 mi | |
| Merge left onto US 30 | 0.4 mi | |
| Take the ramp towards PA 23 East | 0.2 mi | |
| Keep right towards Downtown Lancaster | 300 feet | |
| Go straight onto New Holland Pike | 1,000 feet | |
| Continue onto New Holland Avenue | 1.3 mi | |
| Continue slightly left onto North Plum Street | 0.3 mi | |
| Turn right onto East Orange Street | 900 feet | |
| Turn left onto North Jefferson Street | 300 feet | |
| Turn left onto East Grant Street | 0 feet | |
| Turn right onto North Jefferson Street | 600 feet | |
| Turn right onto East Mifflin Street | 300 feet | |
| Turn right onto South Lime Street (US 222) | 200 feet | |
| You have arrived at your destination |
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Pompton Lakes, New Jersey - Lancaster, Pennsylvania