How to get from Port St Lucie, FL to Gainesville, FL

Discover, print or download the driving directions for the best route to go from Port St Lucie, FL to Gainesville, FL.

Enlarge the route map Port St Lucie, FL - Gainesville, FL

Driving directions from Port St Lucie, FL to Gainesville, FL

Florida's Turnpike, I 75 $north

225.9 mi3 hours 21 mins

Head southeast on Southwest Cameo Boulevard 0.3 mi
Turn left onto Southeast Port Saint Lucie Boulevard 0.4 mi
Turn right onto Southwest Bayshore Boulevard 500 feet
Take the ramp 200 feet
Continue straight 0.5 mi
Keep right towards Orlando 0.3 mi
Merge left onto Florida's Turnpike 122.2 mi
Keep left onto Florida's Turnpike 43.0 mi
Merge left onto I 75 N 46.3 mi
Take the ramp towards CR 234 0.2 mi
Turn right onto Southeast County Road 234 (CR 234) 1.3 mi
Turn left onto US 441 8.1 mi
Turn right onto Southwest Williston Road (FL 331) 0.5 mi
Turn left onto South Main Street (FL 329) 1.6 mi
Go straight onto South Main Street (FL 329) 0.3 mi
Enter the roundabout and take the 2nd exit onto South Main Street (FL 329) 200 feet
Exit the roundabout onto South Main Street (FL 329) 0.5 mi
Turn right onto East University Avenue (FL 20) 700 feet
You have arrived at your destination

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Port St Lucie, FL - Gainesville, FL

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