Pennsylvania Turnpike, US 22 $west
335.0 mi5 hours 35 mins
| Head southeast on River Road (MD 190) | 100 feet | |
| Turn right | 200 feet | |
| Turn right onto Falls Road | 4.7 mi | |
| Continue straight to stay on Falls Road (MD 189) | 500 feet | |
| Take the ramp on the left towards I 270 North | 0.2 mi | |
| Merge left towards I 270 North | 26.1 mi | |
| Take the ramp towards I 70: Hagerstown | 0.4 mi | |
| Keep left towards I 70 West: Hagerstown | 0.4 mi | |
| Merge right onto I 70 | 76.1 mi | |
| Merge left onto Lincoln Highway (US 30) | 1,000 feet | |
| Turn right onto I 70 W | 1.6 mi | |
| Keep right towards I 70 West: Pittsburgh | 0.4 mi | |
| Merge left onto Pennsylvania Turnpike (I 70 W) | 104.8 mi | |
| Take exit 57 towards I 376: Pittsburgh | 0.6 mi | |
| Keep left at the fork | 900 feet | |
| Keep right towards I 376 West: Pittsburgh | 400 feet | |
| Merge right onto Penn-Lincoln Parkway East (I 376 W) | 24.3 mi | |
| Take exit 60A towards US 22 West: Weirton | 26.3 mi | |
| Keep left onto US 22 W | 16.2 mi | |
| Continue onto Cadiz-Steubenville Road (US 22) | 8.4 mi | |
| Take the ramp onto US 250 | 900 feet | |
| Turn right onto Cadiz-Dennison Road (US 250) | 21.2 mi | |
| Take the ramp on the right onto US 250 W | 1.1 mi | |
| Take the ramp towards US 250 West: Uhrichsville | 0.3 mi | |
| Turn right onto Water Street (US 250) | 0.3 mi | |
| Continue onto US 250 W | 11.5 mi | |
| Take exit 83 towards SR 39: Dover | 0.2 mi | |
| Turn left onto State Route 39 (SR 39) | 6.7 mi | |
| Continue onto Dover Road Northeast (SR 39) | 2.4 mi | |
| Continue onto West Main Street (SR 39) | 800 feet | |
| Turn left onto Fair Drive | 0 feet | |
| You have arrived at your destination |
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Potomac, Maryland - Sugarcreek, Ohio