US 69 $south, I 35 $south
549.3 mi8 hours 48 mins
| Head west on East Graham Avenue (OK 20) | 0.3 mi | |
| Turn left onto South Mill Street (US 69 S) | 24.9 mi | |
| Continue onto South Dewey Avenue (US 69 S) | 10.9 mi | |
| Continue onto North 32nd Street (US 69 S) | 3.4 mi | |
| Continue onto South 32nd Street (US 64 E) | 98.7 mi | |
| Continue onto US 69 S | 15.2 mi | |
| Continue towards US 69 South: Durant | 24.8 mi | |
| Take the ramp towards US 70: Durant | 0.3 mi | |
| Turn right onto West Main Street | 3.3 mi | |
| Continue onto US 70 | 2.2 mi | |
| Turn left onto Leavenworth Trail (CR N3660) | 8.2 mi | |
| Take the ramp on the left towards US 69 South: Denison | 900 feet | |
| Merge left onto US 69 S | 81.3 mi | |
| Take the ramp towards Waco | 0.4 mi | |
| Keep left at the fork | 600 feet | |
| Continue onto Woodall Rodgers Freeway (Spur 366 W) | 1.1 mi | |
| Take the ramp towards I 35E South: Waco | 0.5 mi | |
| Merge left onto North Stemmons Freeway (I 35E S) | 5.5 mi | |
| Keep left onto South R L Thornton Freeway (I 35E S) | 6.4 mi | |
| Keep left onto South R L Thornton Freeway (I 35E) | 1.0 mi | |
| Keep left onto South R L Thornton Freeway (I 35E S) | 45.5 mi | |
| Continue onto I 35 S | 6.8 mi | |
| Keep left onto I 35 S | 31.7 mi | |
| Keep left onto Jack Kultgen Expressway (I 35 S) | 13.3 mi | |
| Keep left onto I 35 S | 81.6 mi | |
| Keep right towards Cameron Road | 5.3 mi | |
| Keep left onto I 35 S | 61.6 mi | |
| Keep left onto North Pan-American Expressway (I 35 S) | 6.7 mi | |
| Keep left towards I 35 South | 2.8 mi | |
| Keep left onto North Pan-American Expressway (I 35 S) | 3.7 mi | |
| Keep left towards I 35 South: Lower Level | 0.6 mi | |
| Take the ramp towards Lexington Avenue | 700 feet | |
| Go straight onto East Elmira Street | 500 feet | |
| Turn left onto North Main Avenue | 800 feet | |
| Enter the roundabout and take the 2nd exit onto Navarro Street | 200 feet | |
| Exit the roundabout onto Navarro Street | 0 feet | |
| Keep right onto North Main Avenue | 0.4 mi | |
| Turn right onto West Travis Street | 200 feet | |
| Turn left onto North Flores Street | 0.2 mi | |
| You have arrived at your destination |
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Pryor, Oklahoma - San Antonio, Texas