US 287, I 25 $north
849.9 mi13 hours 18 mins
| Head south on South Main Street (TX 6) | 0.6 mi | |
| Turn right onto West 11th Street (US 287) | 135.3 mi | |
| Take the ramp onto US 287 N | 11.5 mi | |
| Take the ramp towards Bell Street | 700 feet | |
| Go straight onto West Interstate Drive | 0.3 mi | |
| Turn right onto Bell Street | 1.4 mi | |
| Go straight onto West Amarillo Boulevard (I 40-D Business) | 800 feet | |
| Turn left onto Tascosa Road (RM 1061) | 33.6 mi | |
| Turn right onto US 385 | 27.9 mi | |
| Take the ramp onto US 385 | 1.4 mi | |
| Make a slight right onto US 87 N | 12.1 mi | |
| Continue onto US 87 | 38.0 mi | |
| Continue onto United States Highway 87 (US 87 N) | 11.3 mi | |
| Continue onto US 64 | 79.8 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto I 25 N | 107.9 mi | |
| Take the ramp towards 13th Street | 0.4 mi | |
| Merge left onto I 25 N | 0.6 mi | |
| Continue onto I 25 N | 111.9 mi | |
| Keep right onto North Valley Highway (I 25 N) | 100.0 mi | |
| Continue onto I 25 N | 174.7 mi | |
| Take the ramp towards Center Street | 400 feet | |
| Go straight onto East F Street | 800 feet | |
| Turn left onto North Center Street (I 25 Business) | 0.5 mi | |
| Turn right onto West 1st Street (US 20 Business) | 500 feet | |
| You have arrived at your destination |
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Quanah, Texas - Casper, Wyoming