Pennsylvania Turnpike, US 22 $west; US 322 $west
130.9 mi2 hours 19 mins
| Head south on 5th Street (US 222 Business) | 500 feet | |
| Turn right onto Penn Street (US 422 Business Alternate) | 0.3 mi | |
| Continue onto Penn Avenue (US 422 Business Alternate) | 2.6 mi | |
| Take the ramp on the left | 0.3 mi | |
| Merge left onto US 222 | 9.8 mi | |
| Take the ramp towards I 76: PA Turnpike | 0.3 mi | |
| Turn left onto Colonel Howard Boulevard | 0.9 mi | |
| Keep left towards I 76 Toll West: Harrisburg | 0.6 mi | |
| Merge left onto Pennsylvania Turnpike (I 76 W) | 38.9 mi | |
| Take the ramp towards I 283: Harrisburg | 0.2 mi | |
| Continue onto I 283 N | 2.8 mi | |
| Keep left towards I 83 North: Hazleton | 0.3 mi | |
| Continue onto Veterans of Foreign Wars of the United States Memorial Highway (I 83 N) | 3.7 mi | |
| Keep left towards I 81 South: Carlisle | 0.5 mi | |
| Merge right onto American Legion Memorial Highway (I 81 S) | 1.9 mi | |
| Take exit 67A towards US 22 East: Harrisburg | 0.3 mi | |
| Keep right towards US 22 West: Lewistown | 59.4 mi | |
| Take the ramp towards PA 655: Reedsville | 900 feet | |
| Turn left onto State Route 655 (PA 655) | 5.6 mi | |
| Go straight onto East Main Street (PA 655) | 2.3 mi | |
| You have arrived at your destination |
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Reading, Pennsylvania - Belleville, Pennsylvania