I 70 $east; US 40 $east, I 64 $east
1,033.9 mi16 hours 10 mins
| Head east on West 4th Avenue (US 136) | 23.9 mi | |
| Turn right onto Highway 14 (NE 14) | 2.0 mi | |
| Turn left onto Road E | 3.0 mi | |
| Turn right onto Road 3900 | 3.0 mi | |
| Turn left onto Highway 8 (NE 8) | 21.1 mi | |
| Turn right onto Highway 81 (US 81) | 14.6 mi | |
| Turn left | 0.2 mi | |
| Go straight onto US 36 | 31.5 mi | |
| Turn right onto B Street (KS 15) | 0.3 mi | |
| Continue onto Quivira Road (KS 15) | 6.8 mi | |
| Turn left onto 10th Road (KS 9) | 13.3 mi | |
| Continue onto Utah Road (KS 9) | 2.9 mi | |
| Continue onto West Main Street (KS 9) | 0.2 mi | |
| Turn right onto South Colorado Avenue (US 77 S) | 8.6 mi | |
| Continue onto Tuttle Creek Boulevard (US 77 S) | 18.7 mi | |
| Continue onto US 24 E | 15.2 mi | |
| Continue onto Fort Riley Boulevard (KS 177 S) | 0.4 mi | |
| Take the ramp towards Junction I-70 | 8.6 mi | |
| Take the ramp towards I-70 East | 0.2 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 70) | 41.1 mi | |
| Keep left onto Dwight D. Eisenhower Highway (I 70) | 10.5 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 142.4 mi | |
| Keep right onto I 70 E | 8.0 mi | |
| Take the ramp towards I 64 East: Louisville | 0.6 mi | |
| Merge left onto I 64 E | 70.1 mi | |
| Keep right towards I 57 South | 4.6 mi | |
| Take the ramp on the left towards I 64 East: Louisville | 339.4 mi | |
| Take the ramp towards US 25: Corbin | 0.3 mi | |
| Turn left onto Corbin Bypass (US 25E) | 2.0 mi | |
| Continue onto Cumberland Gap Parkway (US 25E) | 30.7 mi | |
| Continue onto Bob Madon Bypass (US 25E) | 10.5 mi | |
| Continue onto Pineville Road (US 25E) | 0.9 mi | |
| Continue onto 12th Street (US 25E) | 3.1 mi | |
| Continue onto Cumberland Gap Parkway (US 25E) | 1.2 mi | |
| Keep right onto Cumberland Gap Parkway (US 25E) | 0.4 mi | |
| Keep left onto Cumberland Gap Parkway (US 25E) | 700 feet | |
| Keep right onto Cumberland Gap Parkway (US 25E) | 500 feet | |
| Keep right onto Cumberland Gap Highway (US 25E) | 0.5 mi | |
| Keep left onto Cumberland Gap Highway (US 25E) | 800 feet | |
| Keep right onto Cumberland Gap Highway (US 25E) | 2.0 mi | |
| Continue onto Cumberland Gap Parkway | 900 feet | |
| Continue onto Highway 25E | 7.1 mi | |
| Continue onto North Broad Street | 3.0 mi | |
| Continue onto Highway 33 South (SR 33) | 10.1 mi | |
| Turn right onto Sharps Chapel Road | 1.1 mi | |
| Turn right to stay on Sharps Chapel Road | 0.2 mi | |
| Turn left to stay on Sharps Chapel Road | 3.1 mi | |
| You have arrived at your destination |
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Red Cloud, Nebraska - Sharps Chapel, Tennessee