I 81 $north, I 64 $east; I 81 $north
249.4 mi4 hours 2 mins
| Head north on South Main Street (US 220 Business) | 0.3 mi | |
| Turn left to stay on North Main Street (US 220 Business) | 2.3 mi | |
| Take the ramp towards US 220 North: Roanoke | 900 feet | |
| Merge left onto Virgil H Goode Highway (US 220 N) | 28.3 mi | |
| Keep right towards I 81 North: Lexington | 14.2 mi | |
| Continue onto I 81 N | 157.8 mi | |
| Take the ramp towards VA 7: Winchester | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto Berryville Pike (VA 7) | 3.5 mi | |
| Continue onto Harry Flood Byrd Memorial Highway (VA 7) | 17.9 mi | |
| Continue onto Harry Flood Byrd Highway (VA 7) | 13.1 mi | |
| Continue onto Leesburg Bypass (VA 7) | 1.5 mi | |
| Take the ramp towards VA 7 East: Tysons Corner | 0.2 mi | |
| Merge left onto East Market Street (VA 7) | 2.1 mi | |
| Continue onto Harry Byrd Highway (VA 7) | 0.7 mi | |
| Continue onto Harry Flood Byrd Highway (VA 7) | 5.9 mi | |
| Turn left onto Palisade Parkway (VA 1795) | 0.5 mi | |
| Turn right onto Cascades Parkway (VA 1794) | 1,000 feet | |
| Take the ramp on the right towards VA 7 West: Leesburg | 0.3 mi | |
| Merge left onto Harry Flood Byrd Highway (VA 7) | 500 feet | |
| You have arrived at your destination |
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Rocky Mount, Virginia - Sterling, Virginia