I 77 $north, I 81 $north
423.0 mi6 hours 57 mins
| Head north on North Main Street (US 221) | 0.9 mi | |
| Go straight | 1,000 feet | |
| Turn right onto Mountain Street (US 64) | 28.4 mi | |
| Continue onto Burkemont Avenue (US 64) | 1.2 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 40 | 49.0 mi | |
| Take the ramp towards I 77 North: Elkin | 0.3 mi | |
| Merge left onto I 77 N | 32.2 mi | |
| Keep right onto I 77 N | 54.1 mi | |
| Take the ramp towards I 81 North: Roanoke | 0.5 mi | |
| Merge left towards I 81 North: Roanoke | 12.0 mi | |
| Continue onto I 81 N | 102.5 mi | |
| Continue onto I 64 E | 99.6 mi | |
| Take the ramp towards US 48: Strasburg | 0.2 mi | |
| Turn left onto John Marshall Highway (US 48) | 8.9 mi | |
| Continue onto Wardensville Pike (US 48) | 5.5 mi | |
| Continue onto US 48 | 14.2 mi | |
| Take the ramp towards WV 29: Baker | 0.2 mi | |
| Turn right onto McCauley Road (WV 29) | 1.2 mi | |
| Make a sharp left onto WV 29 | 6.7 mi | |
| Turn right onto North River (WV 29) | 5.1 mi | |
| You have arrived at your destination |
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Rutherfordton, North Carolina - Delray, West Virginia