US 81 $south; US 287 $south, I 20
336.0 mi5 hours 23 mins
| Head east on 4th Avenue | 300 feet | |
| Turn right onto Avenue G | 0.3 mi | |
| Turn right onto 1st Avenue | 0.2 mi | |
| Turn left | 0.2 mi | |
| Continue onto Sheppard Access Road (Spur 325) | 0.3 mi | |
| Keep left onto Spur 325 | 0.7 mi | |
| Take the ramp towards I 44 West: Wichita Falls | 0.6 mi | |
| Merge right onto Central Freeway (I 44 W) | 2.6 mi | |
| Continue onto Lloyd Ruby Overpass (I 44 W) | 0.9 mi | |
| Continue onto Central East Freeway (US 281 S) | 0.9 mi | |
| Keep right onto Central East Freeway (US 82 E) | 58.4 mi | |
| Continue onto US 81 S | 16.1 mi | |
| Keep left onto US 81 | 1.3 mi | |
| Continue onto US 81 S | 26.8 mi | |
| Keep right towards I 35W South | 0.4 mi | |
| Merge left onto North Freeway (I 35W S) | 2.6 mi | |
| Keep left at the fork | 500 feet | |
| Take the ramp towards I 820 Express East | 1.1 mi | |
| Merge left onto Northeast Loop TEXpress | 6.0 mi | |
| Continue onto Airport Freeway TEXpress | 5.6 mi | |
| Keep left onto SH 183 TEXpress (TX 183 E) | 9.8 mi | |
| Take the ramp towards Carl Road | 0.3 mi | |
| Merge right onto Airport Freeway (TX 183) | 2.2 mi | |
| Continue onto East John Carpenter Freeway (TX 183 E) | 2.2 mi | |
| Merge left onto North Stemmons Freeway (I 35E S) | 5.0 mi | |
| Take the ramp towards I 30 East: Texarkana | 600 feet | |
| Merge right onto Tom Landry Freeway (I 30) | 8.0 mi | |
| Keep right towards US 80 East: Terrell | 19.1 mi | |
| Continue onto Spur 557 E | 4.6 mi | |
| Merge left onto Ronald Reagan Memorial Highway (I 20) | 157.5 mi | |
| Take the ramp | 0.3 mi | |
| Go straight onto Old Minden Road | 0.8 mi | |
| Turn right onto Northgate Road | 1.1 mi | |
| You have arrived at your destination |
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Sheppard Air Force Base - Barksdale Air Force Base, Louisiana