US 59 $south, Eastex Freeway
271.8 mi4 hours 51 mins
| Head southwest on Texas Street (US 79) | 400 feet | |
| Turn left onto Market Street (US 71) | 800 feet | |
| Make a slight right to stay on Market Street (US 71) | 1,000 feet | |
| Take the ramp on the right | 0.5 mi | |
| Merge right onto I 20 | 14.6 mi | |
| Take the ramp towards LA 169 South: Mooringsport | 0.2 mi | |
| Turn left onto Greenwood Mooringsport Road (LA 169) | 0.4 mi | |
| Continue onto US 79 | 29.4 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto Southeast Loop (US 59 S) | 2.1 mi | |
| Continue onto Southwest Loop (TX 149) | 2.4 mi | |
| Turn left onto TX 315 | 24.8 mi | |
| Turn left onto US 259 | 16.8 mi | |
| Take the ramp | 600 feet | |
| Continue straight | 600 feet | |
| Turn left | 100 feet | |
| Merge left onto US 59 | 7.5 mi | |
| Take the ramp | 800 feet | |
| Go straight | 200 feet | |
| Merge left onto South Street (US 59 S) | 20.8 mi | |
| Take the ramp towards US 59 South: Houston | 0.5 mi | |
| Merge right onto South First Street (US 59 S) | 6.4 mi | |
| Continue onto North Temple Drive (US 59 S) | 71.7 mi | |
| Keep left onto Eastex Freeway (I 69 S) | 39.3 mi | |
| Take the ramp towards I 45: Galveston | 0.4 mi | |
| Keep left towards I 45 South: Galverston | 0.4 mi | |
| Continue onto Gulf Freeway (I 45 S) | 25.6 mi | |
| Take the ramp towards FM 517: Dickinson | 0.2 mi | |
| Go straight onto Gulf Freeway Frontage Road | 0.8 mi | |
| Turn right onto FM 517 | 1.0 mi | |
| Turn left onto 16th Street (FM 646) | 4.8 mi | |
| Turn right onto Highway 6 (TX 6) | 0 feet | |
| You have arrived at your destination |
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Shreveport, Louisiana - Santa Fe, Texas