US 65, I 55 $south
656.6 mi11 hours
| Head south on North Mount Olive Street | 1,000 feet | |
| Turn left onto East University Street | 300 feet | |
| Turn right onto North Broadway Street | 800 feet | |
| Continue left onto East Main Street (Siloam Springs) | 1.2 mi | |
| Make a slight right to stay on East Main Street | 500 feet | |
| Turn left onto Highway 412 East (US 412 E) | 3.6 mi | |
| Continue onto US 412 E | 14.1 mi | |
| Continue onto West Sunset Avenue (US 412 E) | 1.3 mi | |
| Take the ramp on the right | 0.2 mi | |
| Merge left onto I 49 S | 51.5 mi | |
| Keep left towards I 40 East: Alma | 0.6 mi | |
| Merge left onto I 40 | 140.3 mi | |
| Take the ramp onto US 65 S | 4.7 mi | |
| Keep left onto I 530 S | 35.0 mi | |
| Take the ramp onto US 65B S | 8.7 mi | |
| Keep right onto US 65B | 900 feet | |
| Keep left onto US 65B | 0.6 mi | |
| Merge left onto I 530 S | 200 feet | |
| Continue onto US 65 | 82.7 mi | |
| Turn right onto US 65 | 35.7 mi | |
| Turn right onto Scarborough Street (US 65) | 27.7 mi | |
| Continue onto North Chestnut Street (US 65) | 1.3 mi | |
| Make a slight right onto Bayou Drive (US 65) | 1.3 mi | |
| Turn left | 0.2 mi | |
| Merge left onto I 20 | 19.4 mi | |
| Merge right onto I 20 | 3.8 mi | |
| Keep right onto I 20 | 38.4 mi | |
| Take the ramp towards I 55 South | 400 feet | |
| Keep left towards I 55 South | 0.7 mi | |
| Merge left onto I 55 S | 156.8 mi | |
| Keep left at the fork | 1.1 mi | |
| Merge left onto I 10 | 24.1 mi | |
| Take the ramp on the left | 0.3 mi | |
| Turn left onto South Claiborne Avenue | 0 feet | |
| Turn right onto Poydras Street | 0.3 mi | |
| Turn left onto Lasalle Street | 800 feet | |
| You have arrived at your destination |
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Siloam Springs, Arkansas - New Orleans, Louisiana