US 77 $north, US 59 $north
414.1 mi8 hours 2 mins
| Head south on Padre Boulevard (PR 100) | 2.3 mi | |
| Turn right onto Queen Isabella Causeway (TX 100) | 2.7 mi | |
| Continue onto East Queen Isabella Boulevard (TX 100) | 0.5 mi | |
| Continue onto State Highway 100 (TX 100) | 1.0 mi | |
| Turn left onto TX 48 | 14.1 mi | |
| Make a slight right | 900 feet | |
| Keep right at the fork | 200 feet | |
| Turn right onto State Highway 550 (TX 550 Toll) | 3.6 mi | |
| Continue onto FM 511 | 1.9 mi | |
| Keep left onto State Highway 550 (TX 550 Toll) | 2.3 mi | |
| Continue onto Interstate 169 (I 169) | 2.1 mi | |
| Merge left onto I 69E N | 32.4 mi | |
| Continue onto I 69E S | 2.8 mi | |
| Continue onto I 69E N | 92.5 mi | |
| Take the ramp | 0.4 mi | |
| Continue onto US HIghway 77 Frontage Road | 2.9 mi | |
| Take the ramp | 0.2 mi | |
| Continue onto I 69E N | 7.8 mi | |
| Merge left onto I 37 N | 2.3 mi | |
| Take the ramp towards Sinton | 35.5 mi | |
| Merge left onto US 77 S | 2.2 mi | |
| Make a slight right onto United States Highway 77 (US 77 N) | 33.1 mi | |
| Keep left onto Spur 91 | 1.5 mi | |
| Merge right onto US 59 N | 54.0 mi | |
| Continue left | 0.5 mi | |
| Continue onto US 59-S Business | 0.5 mi | |
| Turn left onto US 59-S Business | 5.6 mi | |
| Take the ramp onto US 59-S Business | 0.2 mi | |
| Merge left onto US 59 N | 20.6 mi | |
| Take the ramp | 1.1 mi | |
| Continue onto Highway 59 Frontage Road | 5.2 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto US 59 N | 400 feet | |
| Take the ramp | 0.3 mi | |
| Continue onto 59 Northbound Frontage Road | 1.3 mi | |
| Take the ramp | 0.3 mi | |
| Merge left onto US 59 N | 3.3 mi | |
| Continue onto Southwest Freeway (I 69) | 2.5 mi | |
| Keep left onto Southwest Freeway (I 69 N) | 13.7 mi | |
| Take the ramp towards Dairy Ashford Road | 0.3 mi | |
| Merge right onto Southwest Freeway Frontage Road | 1.6 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto Main Street (US 90A) | 4.4 mi | |
| Take the ramp towards Beltway 8 | 0.3 mi | |
| Turn right onto South Sam Houston Parkway West (BW 8) | 800 feet | |
| Take the ramp on the left towards SHT South | 0.2 mi | |
| Merge left onto South Sam Houston Tollway West (SHT) | 17.9 mi | |
| Continue onto South Sam Houston Parkway East (BW 8 E) | 0.2 mi | |
| Take the ramp towards I 45 North: Houston | 0.7 mi | |
| Keep right towards I 45 South: Galveston | 0.6 mi | |
| Merge left onto Gulf Freeway (I 45 S) | 32.1 mi | |
| Continue onto Broadway - Avenue J (TX 87) | 1.7 mi | |
| Turn right onto 37th Street | 200 feet | |
| You have arrived at your destination | 0 feet |
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South Padre Island, Texas - Galveston, Texas