US 77 $north, I 37 $north
395.0 mi6 hours 41 mins
| Head south on Padre Boulevard (PR 100) | 2.3 mi | |
| Turn right onto Queen Isabella Causeway (TX 100) | 2.7 mi | |
| Continue onto East Queen Isabella Boulevard (TX 100) | 0.5 mi | |
| Continue onto State Highway 100 (TX 100) | 1.0 mi | |
| Turn left onto TX 48 | 14.1 mi | |
| Make a slight right | 900 feet | |
| Keep right at the fork | 200 feet | |
| Turn right onto State Highway 550 (TX 550 Toll) | 3.6 mi | |
| Continue onto FM 511 | 1.9 mi | |
| Keep left onto State Highway 550 (TX 550 Toll) | 2.3 mi | |
| Continue onto Interstate 169 (I 169) | 2.1 mi | |
| Merge left onto I 69E N | 32.4 mi | |
| Continue onto I 69E S | 2.8 mi | |
| Continue onto I 69E N | 92.5 mi | |
| Take the ramp | 0.4 mi | |
| Continue onto US HIghway 77 Frontage Road | 2.9 mi | |
| Take the ramp | 0.2 mi | |
| Continue onto I 69E N | 7.8 mi | |
| Merge left onto I 37 N | 125.2 mi | |
| Continue onto William J Bordelon Freeway (I 37 N) | 3.1 mi | |
| Continue towards US 281 North: International Airport | 60.5 mi | |
| Continue onto US 281 | 23.6 mi | |
| Turn left onto 10th Street (RM 1431) | 12.8 mi | |
| You have arrived at your destination |
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South Padre Island, Texas - Kingsland, Texas