US 60, I 40
1,056.1 mi17 hours 10 mins
| Head east on Park Central East | 500 feet | |
| Continue onto East Saint Louis Avenue | 0.8 mi | |
| Turn left onto North National Avenue | 400 feet | |
| Turn right onto East Trafficway Street | 1.2 mi | |
| Go straight onto East Chestnut Expressway (US 65 Business) | 1.5 mi | |
| Take the ramp towards US 65 South | 0.3 mi | |
| Merge left onto Schoolcraft Freeway (US 65 S) | 5.5 mi | |
| Take the ramp towards US 60 East: Cabool | 0.2 mi | |
| Merge left onto US 60 E | 68.7 mi | |
| Continue onto US 60 | 12.9 mi | |
| Continue onto US 60 E | 0.5 mi | |
| Keep left towards US 60 East: Mountain View | 69.5 mi | |
| Continue onto US 60 | 25.5 mi | |
| Continue onto North Westwood Boulevard (US 60 Business) | 800 feet | |
| Make a slight left | 300 feet | |
| Turn left onto Route W (MO W) | 800 feet | |
| Take the ramp on the right | 0.2 mi | |
| Merge left onto US 60 | 74.3 mi | |
| Take the ramp towards US 51 south: Cairo | 200 feet | |
| Continue straight | 0.5 mi | |
| Turn left onto US 51 | 9.7 mi | |
| Turn left onto 4th Street (US 60) | 0.2 mi | |
| Continue onto Lee Street (US 60) | 700 feet | |
| Continue onto North 6th Street (US 60) | 5.9 mi | |
| Continue onto South 4th Street (US 60) | 0.2 mi | |
| Turn right onto Broadway (US 60) | 0.6 mi | |
| Continue onto Paducah Road (US 60) | 3.2 mi | |
| Continue onto West Kentucky Avenue (US 60) | 0.5 mi | |
| Continue onto Paducah Rd (US 60) | 6.1 mi | |
| Continue onto Old Hinkleville Rd (US 60) | 10.6 mi | |
| Take the ramp towards Nashville | 0.2 mi | |
| Merge left onto Interstate 24 (I 24 E) | 133.0 mi | |
| Keep right towards I 24 East: Nashville | 2.3 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep left towards I 40 East: Knoxville | 210.2 mi | |
| Keep right towards I 40 East: Asheville | 217.8 mi | |
| Keep right onto I 40 | 31.8 mi | |
| Merge right onto I 40 | 1.8 mi | |
| Keep left onto I 40 | 36.7 mi | |
| Keep right towards I 40 East: Raleigh | 30.3 mi | |
| Keep right towards Wade Avenue | 3.3 mi | |
| Take the ramp towards I 440 East: Wake Forest | 0.2 mi | |
| Merge left onto I 440 E | 9.5 mi | |
| Take the ramp towards I 87 North: Wilson | 0.7 mi | |
| Continue onto I 87 N | 3.1 mi | |
| Continue onto I-87 | 13.7 mi | |
| Keep right onto US 264 E | 18.6 mi | |
| Continue onto I 795 E | 4.5 mi | |
| Keep left onto US 264 E | 33.2 mi | |
| Continue onto Stantonsburg Road | 2.0 mi | |
| Turn left onto South Memorial Drive (US 13) | 0.4 mi | |
| Turn right onto West 5th Street | 0.7 mi | |
| You have arrived at your destination |
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Springfield, Missouri - Greenville, North Carolina