I 40, I 81 $north
657.9 mi10 hours 5 mins
| Head east on West 5th Avenue (TN 49) | 100 feet | |
| Turn right onto South Main Street | 2.6 mi | |
| Turn right onto Tom Austin Highway (US 431) | 5.9 mi | |
| Continue onto Whites Creek Pike (US 431) | 5.1 mi | |
| Take the ramp on the right | 0.5 mi | |
| Merge left onto I 24 E | 9.2 mi | |
| Keep right towards I 24 East: Nashville | 2.3 mi | |
| Keep left towards I 24 East: Chattanooga | 2.8 mi | |
| Keep left towards I 40 East: Knoxville | 210.2 mi | |
| Keep left towards I 81 North: Bristol | 391.1 mi | |
| Take the ramp towards VA 7: Winchester | 0.2 mi | |
| Keep left at the fork | 300 feet | |
| Turn left onto Berryville Pike (VA 7) | 3.5 mi | |
| Continue onto Harry Flood Byrd Memorial Highway (VA 7) | 5.2 mi | |
| Take the ramp towards US 340: Berryville | 700 feet | |
| Keep left at the fork | 100 feet | |
| Turn left onto Lord Fairfax Highway (US 340 E) | 4.1 mi | |
| Continue onto Berryville Pike (US 340) | 8.7 mi | |
| Take the ramp towards US 340 North: Charles Town | 0.3 mi | |
| Keep right onto US 340 E | 5.4 mi | |
| Turn left onto Union Street | 0.4 mi | |
| Turn right onto Washington Street | 0.3 mi | |
| You have arrived at your destination |
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Springfield, Tennessee - Harpers Ferry, West Virginia