I 75 $north, I 95 $north
405.3 mi6 hours 43 mins
| Head southwest on Punta Vista Drive | 0 feet | |
| Turn left onto Gulf Boulevard (FL 699) | 1.1 mi | |
| Turn left onto Pinellas Bayway (FL 682) | 3.5 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge right onto I 275 N | 42.7 mi | |
| Merge left onto I 75 N | 82.5 mi | |
| Take the ramp towards FL 326 | 0.2 mi | |
| Make a slight right | 100 feet | |
| Merge left onto FL 326 | 2.6 mi | |
| Turn left onto US 301 | 5.5 mi | |
| Keep right towards North US 301: Starke | 48.4 mi | |
| Go straight onto US 301 | 21.7 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto I 10 E | 12.6 mi | |
| Take the ramp towards I-295: Daytona Beach | 0.2 mi | |
| Keep left towards I-295: Daytona Beach | 0.6 mi | |
| Merge left onto I 295 N | 14.2 mi | |
| Take the ramp on the left towards I 95 North: International Airport | 0.5 mi | |
| Merge left onto I 95 N | 140.0 mi | |
| Take the ramp towards US 278: Beaufort | 0.3 mi | |
| Keep right towards US 278 East: Beaufort | 400 feet | |
| Merge left onto Independence Boulevard (US 278) | 6.0 mi | |
| Continue onto Fording Island Road (US 278) | 1.4 mi | |
| Take the ramp | 0.4 mi | |
| Turn left onto Okatie Highway (SC 170) | 14.1 mi | |
| Continue onto Robert Smalls Parkway (SC 170) | 0.4 mi | |
| Turn right onto Savannah Highway (SC 128) | 2.1 mi | |
| Turn right onto Parris Island Gateway (US 21) | 1.2 mi | |
| Continue onto Russell Bell Bridge (US 21) | 0.6 mi | |
| Continue onto Ribaut Road (US 21) | 1.1 mi | |
| Turn right onto Paris Avenue | 0.7 mi | |
| You have arrived at your destination |
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St. Pete Beach, Florida - Port Royal, South Carolina