I 44 $east, I 44 $east; US 50 $east
231.4 mi3 hours 32 mins
| Head east on West Old Rte 66 (125) | 200 feet | |
| Continue onto East Old Route 66 (125) | 0.2 mi | |
| Turn left to stay on 125 | 0.2 mi | |
| Take the ramp on the right | 900 feet | |
| Merge left onto I 44 E | 202.0 mi | |
| Keep right towards I 55 North | 0.8 mi | |
| Keep right towards IL 3 South: East Saint Louis | 1.2 mi | |
| Merge left onto I 55 N | 0.9 mi | |
| Continue onto I 55 N | 700 feet | |
| Keep left towards I 55 North: Chicago | 0.6 mi | |
| Merge right onto I 55 N | 6.1 mi | |
| Take the ramp towards I 255: Memphis | 0.2 mi | |
| Keep left towards I 255 North | 1.2 mi | |
| Merge left onto I 255 N | 4.8 mi | |
| Continue onto Alton Bypass (IL 255 N) | 10.7 mi | |
| Take the ramp towards IL 111 | 0.3 mi | |
| Keep right at the fork | 200 feet | |
| Go straight onto East MacArthur Drive (IL 111) | 0.3 mi | |
| Continue onto West Bethalto Drive (IL 140) | 1.0 mi | |
| Turn left onto South Prairie Street | 0.6 mi | |
| You have arrived at your destination |
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Strafford, Missouri - Bethalto, Illinois