US 6, I 75 $north
184.6 mi3 hours 18 mins
| Head northwest on North Huntington Street (SR 13) | 500 feet | |
| Continue onto Indiana Avenue (SR 13) | 0.6 mi | |
| Continue onto State Road 13 (SR 13) | 1.0 mi | |
| Turn right onto Grand Army of the Republic Hwy (US 6) | 5.1 mi | |
| Continue onto US 6 | 9.0 mi | |
| Turn right onto North County Road 290 West | 0.3 mi | |
| Turn left onto West County Road 700 North (700N) | 0.4 mi | |
| Merge left onto US Highway 6 (US 6) | 2.5 mi | |
| Take the ramp onto US 6 | 2.8 mi | |
| Continue onto US 6 | 4.7 mi | |
| Continue onto W North St (US 6) | 0.7 mi | |
| Continue onto East North Street (US 6) | 3.3 mi | |
| Continue onto Dowling St (US 6) | 17.0 mi | |
| Continue onto West Main Street (US 6) | 1.3 mi | |
| Continue onto Grand Army of the Republic Hwy (US 6) | 2.9 mi | |
| Continue onto Grand Army of the Republic Highway (US 6) | 2.6 mi | |
| Continue onto West Vine Street (US 6) | 0.4 mi | |
| Turn left onto South Michigan Avenue (US 6) | 300 feet | |
| Turn right onto East Indiana Street (US 6) | 0.3 mi | |
| Turn right onto South Ash Street (US 6) | 300 feet | |
| Turn left onto East Morrison Street (US 6) | 31.9 mi | |
| Take the ramp towards US 6 East: Maumee | 4.8 mi | |
| Keep left towards US 24 East: Maumee | 34.6 mi | |
| Continue slightly left onto South Erie Street (SR 25) | 0.9 mi | |
| Turn left onto Cherry Street (SR 25) | 0.2 mi | |
| Turn right onto Greenbelt Parkway (SR 25) | 1.4 mi | |
| Take the ramp towards I 280 North | 0.4 mi | |
| Merge left onto I 280 N | 0.8 mi | |
| Keep right towards I 75 North: Detroit | 0.6 mi | |
| Continue slightly right onto I 75 N | 53.2 mi | |
| Take exit 50 towards Grand River Avenue | 1,000 feet | |
| Continue onto Fisher Drive West | 400 feet | |
| Turn right onto Grand River Avenue (M 5) | 0.5 mi | |
| Turn right onto Griswold Street | 800 feet | |
| Turn left onto Michigan Avenue | 100 feet | |
| You have arrived at your destination |
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Syracuse, Indiana - Detroit, Michigan