US 45, US 45 $south
219.2 mi4 hours 5 mins
| Head south on Main Street (SR 138) | 0.3 mi | |
| Continue onto TN 138 | 1.5 mi | |
| Keep right at the fork | 400 feet | |
| Go straight onto TN 18 | 3.2 mi | |
| Continue onto SR 18 | 3.1 mi | |
| Turn left onto East Market Street (US 64) | 23.0 mi | |
| Continue onto West Court Avenue (US 64 Business) | 0.8 mi | |
| Keep right onto Mulberry Avenue (US 64 Business) | 4.9 mi | |
| Continue onto US 45 | 71.8 mi | |
| Take the ramp onto US 45 S | 24.4 mi | |
| Continue onto US 45 S | 0.4 mi | |
| Continue onto US 45 | 1.5 mi | |
| Continue onto US 45 S | 22.9 mi | |
| Continue onto US 45 | 2.9 mi | |
| Turn left onto North 18th Avenue | 0.4 mi | |
| Take the ramp on the left | 0.2 mi | |
| Merge left onto US 82 E | 55.4 mi | |
| Turn right onto Lurleen B Wallace Boulevard (US 43) | 2.1 mi | |
| Turn left onto University Boulevard | 0.3 mi | |
| You have arrived at your destination, on the left |
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Toone, Tennessee - Tuscaloosa, Alabama