I 70 $east; US 40 $east, I 55 $north
541.7 mi8 hours 26 mins
| Head south on Southeast Monroe Street | 500 feet | |
| Take the ramp | 0.2 mi | |
| Merge left onto Dwight D. Eisenhower Highway (I 70) | 3.1 mi | |
| Keep left towards I-70 East | 2.1 mi | |
| Merge right onto Kansas Turnpike (I 70) | 12.7 mi | |
| Take the ramp towards KS 10: Lecompton | 0.4 mi | |
| Keep right at the fork | 400 feet | |
| Merge left onto South Lawrence Trafficway (KS 10) | 36.4 mi | |
| Keep left towards I 435 East | 0.2 mi | |
| Merge left onto I 435 | 12.2 mi | |
| Keep left towards I 435 North: Des Moines | 9.1 mi | |
| Take exit 63B towards I 70 East: Saint Louis | 0.8 mi | |
| Keep left towards I 70 East: Saint Louis | 500 feet | |
| Merge left onto Truman/Eisenhower Presidential Highway (I 70 E) | 92.2 mi | |
| Keep left onto I 70 E | 46.2 mi | |
| Take exit 148 towards US 54: Auxvasse | 0.2 mi | |
| Turn left onto US 54 E | 18.2 mi | |
| Turn right onto East Liberty Street (US 54) | 10.3 mi | |
| Turn left onto US 54 | 8.1 mi | |
| Turn right to stay on US 54 | 55.5 mi | |
| Turn left onto US 54 | 5.1 mi | |
| Take the ramp on the right towards I 72 East: Springfield | 0.3 mi | |
| Merge left onto I 72 E | 83.5 mi | |
| Continue onto I 55 N | 13.1 mi | |
| Keep right towards I 55 North: Chicago | 29.3 mi | |
| Keep left towards I 55 North: Chicago | 67.9 mi | |
| Continue onto I-55 N | 5.7 mi | |
| Continue onto I 55 N | 20.3 mi | |
| Take exit 250A towards I 80 East: Indiana | 0.8 mi | |
| Merge left onto I 80 | 6.2 mi | |
| Take exit 132B towards US 52 West | 0.2 mi | |
| Go straight onto South Chicago Street (US 52) | 0.9 mi | |
| Turn left onto Washington Street | 0.2 mi | |
| Turn right onto DesPlaines Street | 300 feet | |
| Turn right onto West Jefferson Street (US 30) | 300 feet | |
| You have arrived at your destination |
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Topeka, Kansas - Joliet, Illinois