I 81 $south, Cumberland Gap Parkway
165.3 mi2 hours 57 mins
| Head north on Erwin Highway (SR 173) | 0.6 mi | |
| Turn left onto SR 173 | 0.3 mi | |
| Take the ramp on the right | 0.3 mi | |
| Merge left onto I 26 W | 11.0 mi | |
| Continue onto I 26 W | 12.0 mi | |
| Take exit 8A towards I 81 South: Knoxville | 0.2 mi | |
| Merge left onto I 81 S | 44.6 mi | |
| Take exit 12 towards SR 160: Lowland | 0.3 mi | |
| Turn right onto Enka Highway (SR 160) | 3.2 mi | |
| Take the ramp | 0.2 mi | |
| Merge left onto Davy Crockett Parkway (US 25E) | 5.4 mi | |
| Continue onto Dixie Highway (US 25E) | 4.6 mi | |
| Continue onto New Dixie Highway (US 25E) | 1.4 mi | |
| Continue onto New Lee Highway (US 11W) | 0.9 mi | |
| Continue onto Old Lee Highway (US 11W) | 1.4 mi | |
| Continue onto Dixie Highway (US 25E) | 11.6 mi | |
| Continue onto Highway 25E South (US 25E) | 8.8 mi | |
| Turn right to stay on Highway 25E (US 25E) | 7.1 mi | |
| Continue onto Cumberland Gap Parkway (US 25E) | 2.0 mi | |
| Continue onto Cumberland Gap Highway (US 25E) | 0.2 mi | |
| Keep right onto Cumberland Gap Highway (US 25E) | 0.7 mi | |
| Continue onto Cumberland Gap Parkway (US 25E) | 500 feet | |
| Keep right onto Cumberland Gap Parkway (US 25E) | 1.8 mi | |
| Continue onto Cumberland Gap Tunnel (US 25E) | 3.1 mi | |
| Continue slightly right onto Pineville Road (US 25E) | 0.9 mi | |
| Continue onto Wilderness Road (US 25E) | 10.5 mi | |
| Continue onto Riverview Avenue (US 25E) | 30.1 mi | |
| Turn left onto Master Street (KY 312) | 1.3 mi | |
| Continue onto East Masters Street (KY 312) | 0.7 mi | |
| Turn left onto West 6th | 300 feet | |
| Turn left onto South Main Street (US 25W) | 100 feet | |
| You have arrived at your destination |
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Unicoi, Tennessee - Corbin, Kentucky