I 65 $south, I 40
220.0 mi3 hours 55 mins
| Head east on Grayson Street (KY 224) | 200 feet | |
| Turn right onto North Walnut Street (US 31W) | 0.4 mi | |
| Turn left onto Upton Talley Road (KY 224) | 0.4 mi | |
| Take the ramp on the right | 0.4 mi | |
| Merge left onto I 65 S | 22.8 mi | |
| Take the ramp towards KY 70: Cave City | 0.5 mi | |
| Turn left onto Mammoth Cave Road (KY 70) | 0.2 mi | |
| Continue onto KY 90 | 10.7 mi | |
| Turn right onto North Race Street (US 31E Business) | 0.5 mi | |
| Turn left onto West Water Street | 700 feet | |
| Turn right onto North Broadway (US 68 Business) | 400 feet | |
| Turn left onto East Main Street (KY 90) | 1.1 mi | |
| Continue onto Burkesville Road | 10.9 mi | |
| Continue onto Summer Shade Road (KY 90) | 11.5 mi | |
| Go straight onto Glasgow Road (KY 90) | 10.9 mi | |
| Keep right onto Glasgow Road (KY 90) | 100 feet | |
| Make a slight left onto New Glasgow Highway (KY 90) | 0.6 mi | |
| Merge right onto Glasgow Road (KY 90) | 2.3 mi | |
| Turn right onto North Main Street (KY 61) | 0.8 mi | |
| Turn right onto Celina Road (KY 61) | 12.9 mi | |
| Continue onto Burkesville Highway (SR 53) | 8.8 mi | |
| Turn left onto Livingston Highway (SR 52) | 6.0 mi | |
| Continue onto Celina Highway (SR 52) | 10.1 mi | |
| Turn right onto Bradford Hicks Drive (SR 111) | 1.3 mi | |
| Take the ramp | 600 feet | |
| Turn right onto West Main Street (SR 85) | 0.9 mi | |
| Turn left onto Rickman Road (SR 84) | 0.8 mi | |
| Turn left onto Monterey Highway (SR 84) | 12.9 mi | |
| Continue onto Livingston Highway (SR 84) | 3.4 mi | |
| Continue onto West Commercial Avenue (SR 84) | 0.4 mi | |
| Turn right onto South Holly Street (SR 84) | 0.3 mi | |
| Turn left onto East Stratton Avenue (US 70N) | 0.4 mi | |
| Continue onto Crossville Highway (US 70N) | 900 feet | |
| Take the ramp on the left | 900 feet | |
| Merge left onto I 40 | 86.0 mi | |
| Take the ramp towards Convention Center | 800 feet | |
| Keep left towards Convention Center | 0.5 mi | |
| Go straight onto Henley Street (US 11) | 0.2 mi | |
| You have arrived at your destination |
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Upton, Kentucky - Knoxville, Tennessee