US 22 $east; US 322 $east, Pennsylvania Turnpike
178.1 mi3 hours 7 mins
| Head southwest on Reed Street | 0.3 mi | |
| Turn left | 100 feet | |
| Turn left onto State Route 2029 | 1,000 feet | |
| Continue onto Old Route 322 | 0.2 mi | |
| Make a slight left onto Philipsburg Bigler Highway (US 322) | 4.8 mi | |
| Continue onto North Front Street (US 322) | 0.3 mi | |
| Continue onto North Centre Street (US 322) | 800 feet | |
| Turn left onto Railroad Street (US 322) | 1.0 mi | |
| Continue onto Twenty-Eighth Division Highway (US 322) | 6.5 mi | |
| Continue onto Upper Flat Rock Road (US 322) | 1.6 mi | |
| Continue onto Flat Rock Road (US 322) | 1.5 mi | |
| Continue onto 28th Division Highway (US 322 E) | 12.8 mi | |
| Keep right towards US 322 East: The Pennsylvania State University | 6.3 mi | |
| Continue onto General Potter Highway (US 322) | 78.2 mi | |
| Take the ramp towards I 81 North: Hershey | 1,000 feet | |
| Keep left towards I 81 North: Hershey | 0.9 mi | |
| Merge left onto American Legion Memorial Highway (I 81 N) | 1.8 mi | |
| Take the ramp towards I 83 South: Hershey | 3.5 mi | |
| Keep left onto Veterans of Foreign Wars of the United States Memorial Highway (I 83 S) | 0.8 mi | |
| Keep left towards I 283 South: Airport | 900 feet | |
| Continue onto I 283 S | 2.8 mi | |
| Keep left towards I 76 East: Philadelphia | 0.7 mi | |
| Merge left onto Pennsylvania Turnpike (I 76 E) | 38.7 mi | |
| Take the ramp towards US 222: Reading | 0.2 mi | |
| Continue slightly right onto Colonel Howard Boulevard | 0.7 mi | |
| Take the ramp towards US 222 North: Reading | 0.3 mi | |
| Merge left onto US 222 | 10.0 mi | |
| Take the ramp towards US 422 West: Lebanon | 0.3 mi | |
| Turn right onto Penn Avenue (US 422 Business) | 2.5 mi | |
| Continue onto Penn Street (US 422 Business Alternate) | 0.3 mi | |
| Turn left onto 5th Street (US 222 Business) | 0.2 mi | |
| Turn right onto Walnut Street | 0.3 mi | |
| Turn right onto North 8th Street | 500 feet | |
| You have arrived at your destination |
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Wallaceton, Pennsylvania - Reading, Pennsylvania